University of Rochester Medical Center

April 23, 2004: Immune and Inflammatory Responses in the Central Nervous System

Symposia:

 
  Go to 2004 Schmitt Symposium Page Go to 2004 Schmitt Symposium Page

This all-day event featured six speakers from universities around the country. Approximately fifty professors and students attended the various panels and discussion forums. For a copy of the brochure, click here.

Please browse this website for abstracts and photos about the Symposium presentations:


Welcome Address and Symposium Overview

Neuroscience Graduate Student Irah King (shown to the right) opened the 2004 Schmitt Symposium by welcoming the speakers and the audience. Irah did a great job all day, as he introduced each speaker and shuttled Symposium participants from discussions to lunch to panels to dinner.

Overview: The contribution of inflammation-related processes to neurological diseases has been increasingly recognized in recent years. Studies of primary neuroimmunological diseases such as Multiple Sclerosis as well as neurodegenerative disorders with an inflammatory component, including Alzheimer's Disease and Parkinson's Disease, have received particular attention in basic research and clinical arenas. Inflammatory aspects of CNS trauma, toxin exposure and psychological disorders are also currently under investigation. Furthermore, the immunological/inflammatory consequence of gene therapy in the CNS is a timely and important issue.

This Symposium addressed the roles of innate and adaptive immunity in response to CNS insults and various disease processes. Specific topics included the immune functions of glial cells, factors controlling blood brain barrier integrity, leukocyte trafficking to the CNS, CNS cytokine/chemokine production, animal models of neuroinflammatory/neuroimmunological diseases and clinical application of basic research findings.

2004 Symposium Organizers:

  • Irah King
  • M. Kerry O'Banion, M.D., Ph.D.
  • John Olschowka, Ph.D.
  • Benjamin Segal, M.D.

Irah King, Neuroscience Graduate Student--Welcome Address and Symposium Overview Berislav Zlokovic, M.D., Ph.D.--Intravascular Alzheimer's amyloid-B Linked to AB Deposition in the Brain
Etty Benveniste, Ph.D.--Communication between Immune System and the CNS via Cytokine/Chemokine Networks William Hickey, M.D.--Initiation of Inflammation in the CNS and Regulation of Blood Brain Barrier Integrity
Richard Ransohoff, M.D.--Involvement of Chemokines and Their Receptors in Leukocyte Invasion, Differentiation, Activation, Tissue Destruction, and Repair in the CNS Benjamin Segal, M.D.--Models of Multiple Sclerosis, Experimental Allergic Encephalomyelitis, Mediated by CD4+ T Cells Specific for Myelin Peptides
Joan Goverman, Ph.D.--Mechanisms of Tolerance and Autoimmunity, Experimental Allergic Encephalomyelitis

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