Recent Student Publications

2008

Carlson T, Kroenke M, Rao P, Lane TE and Segal B (2008). The Th17–ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease. 10.1084/jem.2007240.

Elshatory Y and Gan L (2008). The LIM-Homeobox Gene Islet-1 Is Required for the Development of Restricted Forebrain Cholinergic Neurons. J Neurosci 28 3291-3297.

Oberheim NA, Tian GF, Han X, Peng W, Takano T, Ransom B, and Nedergaard M (2008). Loss of Astrocytic Domain Organization in the Epileptic Brain. J Neurosci 28 3264-3276.

Shaftel SS, Griffin WST and O'Banion MK (2008). The role of interleukin-1 in neuroinflammation an Alzheimer disease: an evolving perspective. J Neuroinflammation 5:7.

McGrath KE, Kingsley PD, Koniski AD, Porter RL, Bushnell TP and Palis J (2008). Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus. Blood 111:2409-17.

Mathews MT and Berk BC, Bushnell TP and Palis J (2008). PARP-1 Inhibition Prevents Oxidative and Nitrosative Stress-Induced Endothelial Cell Death via Transactivation of the VEGF Receptor 2. Arterioscler Thromb Vasc Biol Epub ahead of print.

Kaback LA, Soung do Y, Naik A, Smith N, Schwarz EM, O'Keefe RJ and Drissi H (2008). Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification. J Cell Physiol 214:173-82.

2007

White RJ, Meoli DF, Swarthout RF, Kallop DY, Galaria, II, Harvey JL, Miller CM, Blaxall BC, Hall CM, Pierce RA, Cool CD and Taubman MB (2007). Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 293:L583-90.

Weimer JM, Benedict JW, Elshatory YM, Short DW, Ramirez-Montealegre D, Ryan DA, Alexander NA, Federoff HJ, Cooper JD and Pearce DA (2007). Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. Brain Res 1162:98-112.

Elshatory Y, Everhart D, Deng M, Xie X, Barlow RB and Gan L (2007). Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells. J Neurosci 27:12707-20.

Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ and Dewhurst S (2007). HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine 25:7410-21.

Razavi B, O'Neill W, Paige GD (2007). Auditory Spatial Perception Dynamically Realigns with Changing Eye Position. J. Neurosci. 27, 10249-10258.

Lim KC, Tyler CM, Lim ST, Giuliano R, Federoff HJ (2007). Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons. Biochem Biophys Res Commun. 361, 599-604.

Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O'Banion MK (2007). Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. Journal of Neuroscience 27, 9301-9309.

Simning A, van Wijngaarden E (2007). Literature review of cancer mortality and incidence among dentists. Occup Environ Med 64, 432-438.

Elshatory Y, Deng M, Xie X, Gan L (2007). Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina. Journal of Comparative Neurology 503, 182-197.

Kyrkanides S, Fiorentino PM, Miller JN, Gan Y, Lai YC, Shaftel SS, Puzas JE, Piancino MG, O'Banion MK, Tallents RH (2007). Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint. Arthritis Rheumatism 56, 2038-2048.

Lankes HA, Zanghi CN, Santos K, Capella C, Duke CM, Dewhurst S (2007). In vivo gene delivery and expression by bacteriophage lambda vectors. Journal of Applied Microbiology 102, 1337-1349.

Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S (2007). Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine 25, 1634-1646.

Shaftel SS, Kyrkanides S, Olschowka JA, Miller JH, Johnson RE, O'Banion MK (2007). Sustained hippocampal IL-1ß overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. Journal of Clinical Investigation 117, 1595-1604.

Zanghi CN, Sapinoro R, Bradel-Tretheway B, Dewhurst S (2007). A tractable method for simultaneous modifications to the head and tail of bacteriophage lambda and its application to enhancing phage-mediated gene delivery. Nucleic Acids Research 35, e59.

2006

Suzuki J, Jin ZG, Meoli DF, Matoba T, Berk BC (2006). Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells. Circulation Research 98, 811-817.

Oberheim NA, Wang X, Goldman S, Nedergaard M (2006). Astrocytic complexity distinguishes the human brain. Trends in Neurosciences 29, 547-553.

Bellizzi MJ, Lu S-M, Gelbard HA (2006). Protecting the synapse: evidence for a rational strategy to treat HIV infection associated neurologic disease. Neuroimmune Pharmacology 1, 20-31.

Hoefen RJ, Berk BC (2006). The multifunctional GIT family of proteins. J. Cell Sci. 119, 1469-1475.

Lai YC, Shaftel SS, Miller JN, Tallents RH, Chang Y, Pinkert CA, Olschowka JA, Dickerson IM, Puzas JE, O'Banion MK, Kyrkanides S (2006). Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain. Arthritis Rheum. 54, 1184-1197

Homsy JG, Jasper H, Peralta XG, Wu H, Kiehart DP, Bohmann D (2006). JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. J Dev Dyn. 235, 427-34.

Bellizzi MJ, Lu SM, Masliah E, Gelbard HA (2006). Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor. J Clin Invest 115, 3185-92.

2005

Garin G, Mathews M, and Berk BC (2005). Tissue-resident bone marrow-derived progenitor cells: key players in hypoxia-induced angiogenesis. Circ. Res. 97, 955-957.

Zanghi CN, Lankes HA, Bradel-Tretheway B, Wegman J, Dewhurst S (2005). A simple method for displaying recalcitrant proteins on the surface of bacteriophage lambda. Nucleic Acids Res. 33, e160.

Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X, Zielke HR, Kang J, and Nedergaard M (2005). An astrocytic basis of epilepsy. Nature Medicine 11, 973-981.

Arndt TL, Stodgell CJ, and Rodier PM (2005). The teratology of autism. Int J Dev Neurosci 23, 189-199.

Flores AR, Parsons LM, and Pavelka MS, Jr. (2005a). Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to beta-lactam antibiotics. J Bacteriol 187, 1892-1900.

Flores AR, Parsons LM, and Pavelka MS, Jr. (2005b). Genetic analysis of the beta-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to beta-lactam antibiotics. Microbiology 151, 521-532.

Webster RL, and Johnson RP (2005). Delineation of multiple subpopulations of natural killer cells in rhesus macaques. Immunology 115, 206-214.

OBerheim, NA (2005). Cover Illustration. Glia 50, Issue 4; April 21.

2004

Diamond TL, Roshal M, Jamburuthugoda VK, Reynolds HM, Merriam AR, Lee KY, Balakrishnan M, Bambara RA, Planelles V, Dewhurst S, and Kim B (2004). Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J Biol Chem 279, 51545-51553.

Dietrich J, Blumberg BM, Roshal M, Baker JV, Hurley SD, Mayer-Proschel M, Mock DJ. (2004). Infection with an endemic human herpesvirus disrupts critical glial precursor cell properties. J Neurosci, 24, 4875-83.

Gildner CD, Lerner AL, and Hocking DC (2004). Fibronectin matrix polymerization increases tensile strength of model tissue. Am J Physiol Heart Circ Physiol 287, H46-53.

Mathews DH, Disney MD, Childs JL, Schroeder SJ, Zuker M, and Turner DH (2004). Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure. Proc Natl Acad Sci U S A 101, 7287-7292.

Ruschak AM, Mathews DH, Bibillo A, Spinelli SL, Childs JL, Eickbush TH, and Turner DH (2004). Secondary structure models of the 3' untranslated regions of diverse R2 RNAs. Rna 10, 978-987.

van Nieuw Amerongen GP, Natarajan K, Yin G, Hoefen RJ, Osawa M, Haendeler J, Ridley AJ, Fujiwara K, van Hinsbergh VW, and Berk BC (2004). GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions. Circ Res 94, 1041-1049.

2003

Huang W, Drissi MH, O'Keefe RJ, and Schwarz EM (2003a). A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis. Calcif Tissue Int 73, 584-593.

Huang W, O'Keefe RJ, and Schwarz EM (2003b). Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation. Arthritis Res Ther 5, R49-59.

Kenny AP, Oleksyn DW, Newman LA, Angerer RC, and Angerer LM (2003). Tight regulation of SpSoxB factors is required for patterning and morphogenesis in sea urchin embryos. Dev Biol 261, 412-425.

Lim KC, Lim ST, and Federoff HJ (2003). Neurotrophin secretory pathways and synaptic plasticity. Neurobiol Aging 24, 1135-1145.

Richards J, Miller M, Abend J, Koide A, Koide S, and Dewhurst S (2003a). Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin. J Mol Biol 326, 1475-1488.

Richards J, Abend JR, Miller ML, Chakraborty-Sett S, Dewhurst S, and Whetter LE (2003b). A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells. Eur J Biochem 270, 2287-2294.

Roda RH, Balakrishnan M, Hanson MN, Wohrl BM, Le Grice SF, Roques BP, Gorelick RJ, and Bambara RA (2003). Role of the Reverse Transcriptase, Nucleocapsid Protein, and Template Structure in the Two-step Transfer Mechanism in Retroviral Recombination. J Biol Chem 278, 31536-31546.

Roshal M, Kim B, Zhu Y, Nghiem P, and Planelles V (2003). Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R. J Biol Chem 278, 25879-25886.

Shaftel SS, Olschowka JA, Hurley SD, Moore AH, and O'Banion MK (2003). COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells. Brain Res Mol Brain Res 119, 213-215.

Zhu Y, Roshal M, Li F, Blackett J, and Planelles V (2003). Upregulation of survivin by HIV-1 Vpr. Apoptosis 8, 71-79.

2002

Berk BC, Min W, Yan C, Surapisitchat J, Liu Y, and Hoefen R (2002). Atheroprotective Mechanisms Activated by Fluid Shear Stress in Endothelial Cells. Drug News Perspect 15, 133-139.

Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff HJ, and Fong Y (2002). Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Ann Surg 236, 337-342; discussion 342-333.

Froehler MT, and Duffy CJ (2002). Cortical neurons encoding path and place: where you go is where you are. Science 295, 2462-2465.

Hoefen RJ, and Berk BC (2002). The role of MAP kinases in endothelial activation. Vascul Pharmacol 38, 271-273.

Hojo Y, Saito Y, Tanimoto T, Hoefen RJ, Baines CP, Yamamoto K, Haendeler J, Asmis R, and Berk BC (2002). Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism. Circ Res 91, 712-718.

Huang W, and Schwarz EM (2002). Mechanisms of bone resorption and new bone formation in spondyloarthropathies. Curr Rheumatol Rep 4, 513-517.

Mathews DH, and Turner DH (2002a). Dynalign: an algorithm for finding the secondary structure common to two RNA sequences. J Mol Biol 317, 191-203.

Mathews DH, and Turner DH (2002b). Experimentally derived nearest-neighbor parameters for the stability of RNA three- and four-way multibranch loops. Biochemistry 41, 869-880.

Perry SW, Dewhurst S, Bellizzi MJ, and Gelbard HA (2002). Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk. J Neurovirol 8, 611-624.

Roda RH, Balakrishnan M, Kim JK, Roques BP, Fay PJ, and Bambara RA (2002). Strand transfer occurs in retroviruses by a pause-initiated two-step mechanism. J Biol Chem 277, 46900-46911.

Znosko BM, Burkard ME, Krugh TR, and Turner DH (2002a). Molecular recognition in purine-rich internal loops: thermodynamic, structural, and dynamic consequences of purine for adenine substitutions in 5'(rGGCAAGCCU)2. Biochemistry 41, 14978-14987.

Znosko BM, Burkard ME, Schroeder SJ, Krugh TR, and Turner DH (2002b). Sheared Aanti.Aanti base pairs in a destabilizing 2 x 2 internal loop: the NMR structure of 5'(rGGCAAGCCU)2. Biochemistry 41, 14969-14977.