Sally A. Quataert Director, Human Immunology Center Core Laboratory; Research Associate Professor of Microbiology & Immunology Primary Appointment:  Microbiology & Immunology Center Affiliation: Center for Vaccine Biology and Immunology: Human Immunology Center GEBS Cluster Affiliations:  Immunology, Microbiology, and Virology - IMV
	Contact Information
	University of Rochester School of Medicine and Dentistry 601 Elmwood Ave, Box 609 Rochester, New York 14642	Phone: (585) 273-2454 E-Mail: Sally_Quataert@ urmc.rochester.edu

Research Focus

Standardization of immunological techniques for clinical investigation of human immune status.

Research Overview

The mission of the Human Immunology Center is to provide expertise for applying new cutting edge immunological techniques from basic animal research through development and standardization to human research.  Research in the HIC core laboratory supports exploratory clinical research programs by establishing measures for immune status and response across multiple disciplines and programs.

Standard procedures using 18-color multichromatic flow cytometry for cell analysis and 15-color cell sorting, Elispot, fluorispot and lysispot are available for application to clinical trials  including lymphoma, autoimmunity, and infectious disease.  New techniques provide insight into T, B, dendritic and antigen presenting cell regulation, activation and interactions.  Standardized reagent panels for human cell differentiation and activation markers provide the consistency needed to allow interpretation of complex data from analysis of human immune compartments.

Recent Publications

Hu, B. T., X. Yu, et al. (2005). "Approach to validating an opsonophagocytic assay for Streptococcus pneumoniae." Clin Diagn Lab Immunol 12(2): 287-95.

Sikkema, D. J., N. A. Ziembiec, et al. (2005). "Assignment of weight-based immunoglobulin G1 (IgG1) and IgG2 units in antipneumococcal reference serum lot 89-S(F) for pneumococcal polysaccharide serotypes 1, 4, 5, 7F, 9V, and 18C." Clin Diagn Lab Immunol 12(1): 218-23.

Quataert SA, Rittenhouse-Olson K, Kirch CS, Hu B, Secor S, Strong N, Madore DV. "Assignment of weight-based antibody units for 13 serotypes to a human antipneumococcal standard reference serum, lot 89-S(f)."  Clin Diagn Lab Immunol. 2004 Nov;11(6):1064-9.

Wernette CM, Frasch CE, Madore D, Carlone G, et al. "Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharides."  Clin Diagn Lab Immunol. 2003 Jul;10(4):514-9. 

Quataert S, Martin D, Anderson P, Giebink GS, Henrichsen J, et al. "A multi-laboratory evaluation of an enzyme-linked immunoassay quantitating human antibodies to Streptococcus pneumoniae polysaccharides." Immunol Invest. 2001 Aug;30(3):191-207.

Rennels MB, Edwards KM, Keyserling HL, et al. "Safety and immunogenicity of four doses of Neisseria meningitidis group C vaccine conjugated to CRM197 in United States infants." Pediatr Infect Dis J. 2001 Feb;20(2):153-9.

English M, MacLennan JM, Bowen-Morris JM, et al. "A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants." Vaccine. 2000 Dec 8;19(9-10):1232-8.

Choo S, Seymour L, Morris R, Quataert S, Lockhart S, Cartwright K, Finn A. Immunogenicity and reactogenicity of a pneumococcal conjugate vaccine administered combined with a haemophilus influenzae type B conjugate vaccine in United Kingdom infants.  Pediatr Infect Dis J. 2000 Sep;19(9):854-62.

Sikkema DJ, Friedman KE, Corsaro B, Kimura A, Hildreth SW, Madore DV, Quataert SA. Relationship between serum bactericidal activity and serogroup-specific immunoglobulin G concentration for adults, toddlers, and infants immunized with neisseria meningitidis serogroup C vaccines. Clin Diagn Lab Immunol. 2000 Sep;7(5):764-8.

Madore DV, Quataert SA. Interlaboratory reproducibility of an enzyme-linked immunosorbent assay for quantitation of antibodies for Haemophilus influenzae type b polysaccharide.  Clin Diagn Lab Immunol. 1999 May;6(3):446.

Diakun KR, Martin DC, Mininni T, Skuse J, Ziembiec N, Quataert S. Immunoassay of human Neisseria meningitidis serogroup A antibody. Immunol Invest. 1998 JulSep;27(4-5):203-20.

Publication list, as provided by PubMed.

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