 M.D. (1976) | Michael
Pichichero Professor of Microbiology & Immunology Primary
Appointment: GEBS
Cluster Affiliations: |
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| Contact Information: | ||
| University
of Rochester School of Medicine and Dentistry 601 Elmwood Ave, Box 672 Rochester, New York 14642 | Medical
Center 2-5431 Phone: (585) 275-1534 E-Mail: michael_pichichero @urmc.rochester.edu | |
- Research Focus
- Vaccine Development and Evaluation
- Research Overview
- Dr. Pichichero and his colleagues' vaccine studies helped define the key variables that determine immunogenicity of the Haemophilus influenzae b (Hib) conjugate vaccines in the young infant. Encouraging findings have been made with Streptococcus pneumoniae capsular polysaccharide vaccines of several serotypes employing the conjugate vaccine technology. Continuation of these studies should further define structural factors governing immunogenicity of conjugate vaccines, analyze the role of epitopes of the carrier component, and pursue structure-immunogenicity relationships in conjugates of specific pneumococcal serotypes.
- Combination vaccines are a necessity for the future of human vaccine development. The immunogenicity of acellular pertussis (DTaP) vaccines combined with various Hib conjugate vaccines, Hepatitis B vaccine, and inactivated poliovirus vaccine results in reduced immunogenicity for some of the included antigens. The mechanism(s) and biological relevance of this immunologic interference phenomena is an area of active research in Dr. Pichichero's lab.
- Bacteria resistant to standard antibiotic therapy are causing acute otitis media with increasing frequency. New antibiotics are needed to cure these infections and to prevent long-term middle ear disease and associated hearing loss. Dr. Pichichero's group studies the epidemiology, etiology, and optimal treatment of otitis media. Sore throat caused by Group A beta hemolytic streptococci occur with concomitant colonization by organisms that may protect the streptococci through beta lactamase inactivation of penicillin at the site of infection. Dr. Pichichero's group evaluates alternative treatments to decrease the relapse rate of streptococcal infections.
- Recent Publications
- Casey JR, Kahn R, Gmoser D, Atlas E, Urbani K, Luber S, Pellman H, Pichichero ME Frequency of Symptomatic Relapses of Group A {beta}-Hemolytic Streptococcal Tonsillopharyngitis in Children from 4 Pediatric Practices Following Penicillin, Amoxicillin, and Cephalosporin Antibiotic Treatment. Clin Pediatr (Phila). 2008 May 19;
- Noel GJ, Blumer JL, Pichichero ME, Hedrick JA, Schwartz RH, Balis DA, Melkote R, Bagchi P, Arguedas A A Randomized Comparative Study of Levofloxacin Versus Amoxicillin/Clavulanate for Treatment of Infants and Young Children With Recurrent or Persistent Acute Otitis Media. Pediatr Infect Dis J. 2008 Apr 30;
- Pichichero ME, Casey JR Comparison of study designs for acute otitis media trials. Int J Pediatr Otorhinolaryngol. 2008 Apr 7;
- Pichichero ME Improving Vaccine Delivery Using Novel Adjuvant Systems. Hum Vaccin. 2008 Feb 15;4(4)
- Pichichero ME, Casey JR Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era. Pediatr Infect Dis J. 2007 Oct;26(10 Suppl):S12-6
- Pichichero ME, Casey JR, Block SL, Guttendorf R, Flanner H, Markowitz D, Clausen S Pharmacodynamic Analysis and Clinical Trial of Amoxicillin Sprinkle QD for 7 Days Compared to Penicillin VK QID for 10 Days in the Treatment of Tonsillopharyngitis due to Streptococcus Pyogenes in Children. Antimicrob Agents Chemother. 2008 Mar 10
- Zeng M, Xu Q, Elias M, Pichichero ME, Simpson LL, Smith LA Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine.Vaccine. 2007 Oct 23;25(43):7540-8
- Pichichero ME, Gentile A, Giglio N, Umido V, Clarkson T, Cernichiari E, Zareba G, Gotelli C, Gotelli M, Yan L, Treanor J " Mercury levels in newborns and infants after receipt of thimerosal-containing vaccines." Pediatrics. 2008 Feb;121(2):e208-14
- Pichichero ME, Casey JR "Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era." Pediatr Infect Dis J. 2007 Oct;26(10 Suppl):S12-6
- Pichichero ME, Casey JR "Systematic review of factors contributing to penicillin treatment failure in Streptococcus pyogenes pharyngitis" Otolaryngol Head Neck Surg. 2007 Dec;137(6):851-857
- Casey JR, Pichichero ME "Symptomatic relapse of group A beta-hemolytic streptococcal tonsillopharyngitis in children." Clin Pediatr (Phila). 2007 May;46(4):307-10
- Pichichero ME, Casey JR "Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children." JAMA. 2007 Oct 17;298(15):1772-8
- Pichichero ME, Casey JR "Bacterial eradication rates with shortened courses of 2nd- and 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adults." Diagn Microbiol Infect Dis. 2007 Oct;59(2):127-30
- Zeng M, Xu Q, Elias M, Pichichero ME, Simpson LL, Smith LA "Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine." Vaccine. 2007 Sep 5;
- Pichichero ME "Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift." Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):13S-18S
- Casey JR, Pichichero ME. "The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis." Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):39S-45S
- Denoël PA, Goldblatt D, de Vleeschauwer I, Jacquet JM, Pichichero ME, Poolman JT "Quality of the Haemophilus influenzae type b antibody response induced by DTPa/Hib combination vaccines." Clin Vaccine Immunol. 2007 Aug 15;
- Pichichero ME "The Importance of Bacteriologic Eradication in the Treatment of Group A Streptococcal Tonsillopharyngitis." Clin Pediatr (Phila). 2007 May;46(4_suppl):3S-16S
- Casey JR, Pichichero ME. "Symptomatic Relapse of Group A {beta}-Hemolytic Streptococcal Tonsillopharyngitis in Children." Clin Pediatr (Phila). 2007 May;46(4):307-10
- Pichichero ME "Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift." Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):S13-8
- Pichichero ME. "Who should get the HPV vaccine?" J Fam Pract. 2007 Mar;56(3):197-202
- Casey JR, Pichichero ME. "Safe use of selected cephalosporins in penicillin-allergic patients: A meta-analysis." Otolaryngol Head Neck Surg. 2007 Mar;136(3):340-7.
- Casey JR, Pichichero ME. "The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis." Diagn Microbiol Infect Dis. 2007 Feb 8;
- Zeng M, Xu Q, Pichichero ME. "Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine." Vaccine. 2007 Jan 26;
- Pichichero ME, Casey JR, Francis AB, Marsocci SM, Murphy M, Hoeger W, Cleary C. "Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules." Clin Pediatr (Phila). 2006 Sep;45(7):613-20.
- Farrell DJ, Klugman KP, Pichichero M. "Increased Antimicrobial Resistance Among Nonvaccine Serotypes of Streptococcus pneumoniae in the Pediatric Population After the Introduction of 7-Valent Pneumococcal Vaccine in the United States." Pediatr Infect Dis J. 2007 Feb;26(2):123-128.
- Arguedas A, Dagan R, Pichichero M, Leibovitz E, Blumer J, McNeeley DF, Melkote R, Noel GJ "An Open-Label, Double Tympanocentesis Study of Levofloxacin Therapy in Children With, or at High Risk for, Recurrent or Persistent Acute Otitis Media." Pediatr Infect Dis J. 2006 Dec;25(12):1102-1109
- Pichichero M, Papa T, Blatter M, Mitchell D, Kratz R, Sneed J, Bassily E, Casey J, Gilmet G "Immune Memory in Children Previously Vaccinated With an Experimental Quadrivalent Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine." Infect Dis J. 2006 Nov;25(11):995-1000
- Pichichero ME, Casey JR, Francis AB, Marsocci SM, Murphy M, Hoeger W, Cleary C "Acellular Pertussis Vaccine Boosters Combined With Diphtheria and Tetanus Toxoid Boosters for Adolescents: Safety and Immunogenicity Assessment When Preceded by Different 5-Dose DTaP/DTwP Schedules." Clin Pediatr (Phila). 2006 Sep;45(7):613-20
- Pichichero ME, Pathogen shifts and changing cure rates for otitis media and tonsillopharyngitis Clin Pediatr (Phila). 2006 Jul-Aug;45(6):493-502
- Pichichero ME, Prevention of cervical cancer through vaccination of adolescents. Clin Pediatr (Phila). 2006 Jun;45(5):393-8
- Pichichero M, "Rotavirus Vaccine (RotaTeq((R))): A Viewpoint by Michael E. Pichichero" Paediatr Drugs. 2006; 8(3):203-4
- Pichichero M, Casey J. "Comparison of European and U.S. results for cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis." Eur J Clin Microbiol Infect Dis. 2006 Jun;25(6):354-64
- Pichichero ME, Wright T. "The use of tympanocentesis in the diagnosis and management of acute otitis media." Curr Infect Dis Rep. 2006 May;8(3):189-95.
- Pichichero ME, DeTora LM, Johnson DR. "An adolescent and adult formulation combined tetanus, diphtheria and five-component pertussis vaccine." Expert Rev Vaccines. 2006 Apr;5(2):175-87.
Publication
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