Ph.D. (1998) University of California, Berkeley

Derick Peterson Associate Professor of Biostatistics and Computational Biology   Director, Biostatistics Shared Resource for the James P. Wilmot Cancer Center     Contact Information: University of Rochester Dept of Biostatistics and Computational Biology 601 Elmwood Avenue Box 630 Rochester, New York 14642   Office: MRBX G-11311G Phone: (585) 275-6686 Fax: (585) 273-1031 E-mail: Peterson (at) bst.rochester.edu

Research Interests

Methodological research topics of particular interest to me include the construction of prognostic gene expression profiles from high-dimensional microarray data, model selection, nonparametric estimation and inference, data-driven smoothing methods, and the analysis of censored survival data.

My experience in applied medical & epidemiological research includes collaborative work on Long-QT Syndrome (Heart Research), the Program of All-Inclusive Care for the Elderly (Community & Preventive Medicine), Respiratory Syncytial Virus (Infectious Diseases), HIV & cognitive functioning (Neurology), bioterrorism detection (Monroe County Health Department), and cancer research.

Currently, I am developing novel methods for the construction of prognostic gene expression profiles based on censored survival and high-dimensional microarray data for breast cancer patients. My goal is to move beyond the limited univariate methods most often employed for selecting genes and make some use of the multivariate structure of the correlated gene expressions as well as important clinical covariates.

I joined the Biostatistics faculty at the University of Rochester in 1998, directly after receiving my PhD in Biostatistics from UC-Berkeley, under the supervision of Prof. Mark J. van der Laan and Prof. Kjell A. Doksum.
 

Technical reports

• Peterson, D. (2006). Constructing Multivariate Prognostic Gene Signatures with Censored Survival Data. (Technical Report 06/09).

Selected References

• van der Laan, M.J., Jewell, N.P., and Peterson, D.R. (1997). Efficient estimation of the lifetime and disease onset distribution. Biometrika 84:539-554.
• Doksum, K., Peterson, D., and Samarov, A. (2000). On variable bandwidth selection in local polynomial regression. Journal of the Royal Statistical Society, Series B (Statistical Methodology) 62:431-448.
• Moss, A.J., Zareba, W., Kaufman, E.S., Gartman, E., Peterson, D.R., et. al. (2002). Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the Human Ether-a-go-go-Related Gene potassium channel. Circulation 105:794-799.
• Zareba, W., Moss, A.J., Locati, E.H., Lehmann, M.H., Peterson, D.R., Hall, W.J., Schwartz, P.J., Vincent, G.M., Priori, S.G., Benhorin, J., Towbin, J.A., Robinson, J.L., Andrews, M.L., Napolitano, C., Timothy, K., Zhang, L., Medina, A. (2003). Modulating effects of age and gender on the clinical course of long QT syndrome by genotype. Journal of the American College of Cardiology 42:103-109.
• Peterson, D.R., Zhao, H., and Eapen, S. (2003). Using local correlation in kernel-based smoothers for dependent data. Biometrics 59:984-991.
• Walsh, E.E., Peterson, D.R., and Falsey, A.R. (2004). Risk factors for severe Respiratory Syncytial Virus infection in elderly adults. Journal of Infectious Diseases 189:233-238.
• van Haren, K., van der Voorn, J.P., Peterson, D.R., van der Knaap, M.S., and Powers, J.M. (2004). The life and death of oligodendrocytes in vanishing white matter disease. Journal of Neuropathology and Experimental Neurology 63:618-630.
• Mukamel, D.B., Peterson, D.R., Bajorska, A., Temkin-Greener, H., Kunitz, S., Gross, D., and Williams, T.F. (2004). Variations in risk-adjusted outcomes in a managed acute/long-term care program for frail elderly individuals. International Journal for Quality in Health Care 16:293-301.
• Podgorski, C., Kessler, K., Cacia, B., Peterson, D., and Henderson, M. (2004). A fitness intervention for older adults with developmental disabilities: Report on a pilot project. Mental Retardation 42:272-283.
• Temkin-Greener, H., Bajorska, A., Peterson, D.R., Kunitz, S.J., Gross, D., Williams, T.F., and Mukamel, D.B. (2004). Social support and risk-adjusted mortality in a frail older population. Medical Care 42:779-788.
• DiCenzo, R., Peterson, D., Cruttenden, K., Morse, G., Riggs, G., Gelbard, H., and Schifitto, G. (2004). Effects of valproic acid coadministration on Efavirenz and Lopinavir/ritonavir plasma concentration in HIV-infected adults. Antimicrobial Agents and Chemotherapy 48:4328-4331.
• Guzman, M.L., Rossi, R.M., Karnischky, L., Li, X., Peterson, D.R., Howard, D.S., and Jordan, C.T. (2005). The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 105:4163-4169.
• Moss, A.J., Peterson, D.R., Zareba, W., Seth, R., McNitt, S.A., Andrews, M.L., Ackerman, M.J., Benhorin, J., Kaufman, E.S., Napolitano, C., Priori, S.G., Robinson, J.L., Schwartz, P.J., Towbin, J.A., Vincent, G.M., and Zhang, L. (2005). Beta-blocker efficacy in Long QT Syndrome patients with mutations in the pore and nonpore regions of the hERG potassium-channel gene. New Arrhythmia Technologies. Wang, P., Naccarelli, G., Rosen, M., Estes, M., Hayes, D., and Haines, D., ed. Blackwell Publishing, Cambridge.
• Mukamel, D.B., Temkin-Greener, H., Delavan, R., Peterson, D.R., Gross, D., Kunitz, S., and Williams, T.F. (2006). Team performance and risk-adjusted health outcomes in the Program of All-Inclusive Care for the Elderly. The Gerontologist 46:227-237.
• Schifitto, G., Peterson, D.R., Zhong, J., Ni, H., Cruttenden, K., Gaugh, M., Gendelman, H.E., Boska, M., and Gelbard, H. (2006). Valproic acid adjunctive therapy for HIV-associated cognitive impairment: A preliminary report. Neurology 66:919-921.
• Goldenberg, I., Matthew, J., Moss, A.J., McNitt, S., Peterson, D.R., Zareba, W., Benhorin, J., Zhang, L., Vincent, M., Andrews, J.L., Robinson, J.L., and Murray, B. (2006). QTc variability in serial ECGs in Long QT Syndrome: The importance of the maximum QTc for risk stratification. Journal of the American College of Cardiology 47:1811–1817.
• Narins, C.R., Ling, F.S., Fischi, M., Peterson, D.R., Bausch, J., and Zareba W. (2006). In-hospital mortality among women undergoing contemporary elective percutaneous coronary intervention: A reexamination of the gender-gap. Clinical Cardiology 29:254–258.
• Hobbs, J.B., Peterson, D.R., Moss, A.J., McNitt, S., Zareba, W., Goldenberg, I., Qi, M., Robinson, J.L., Sauer, A.J., Ackerman, M.J., Benhorin, J., Kaufman, E.S., Locati, E.H., Napolitano, C., Priori, S.G., Towbin, J.A., Vincent, G.M., and Zhang, L. (2006). Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the Long-QT Syntrome. Journal of the American Medical Association 296:1249-1254.
• Sauer, A.J., Moss, A.J., McNitt, S., Peterson, D.R., Zareba, W., Robinson, J.L., Qi, M., Goldenberg, I., Hobbs, J.B., Ackerman, M.J., Benhorin, J., Hall, W.J., Kaufman, E.S., Locati, E.H., Napolitano, C., Priori, S.G., Schwartz, P.J., Towbin, J.A., Vincent, G.M., and Zhang, L. (2007). Long QT Syndrome in adults. Journal of the American College of Cardiology 49:329-337.
• Walsh, E.E., Peterson, D.R., and Falsey, A.R. (2007). Is Clinical Recognition of Respiratory Syncytial Virus Infection in Hospitalized Elderly and High-Risk Adults Possible? The Journal of Infectious Diseases 195:1046-1051.
• Mukamel, D.B., Peterson, D.R., Temkin-Greener, H., Delavan, R., Gross, D., Kunitz, S., and Williams, T.F. (2007). Program characteristics and enrollees' outcomes in the Program of All-Inclusive Care for the Elderly (PACE). The Milbank Quarterly 85: 499-531.
• Bazarian, J.J., Zhong, J., Blyth, B., Zhu, T., Kavcic, V., and Peterson, D.R. (2007). Diffusion tensor imaging detects clinically important axonal injury after mild traumatic brain injury. Journal of Neurotrauma 24:1447-1459.
• Frank, S., Wilson, R., Holloway, R., Zimmerman, C., Peterson, D.R., Kieburtz, K., Kim, S.Y.H. (2008). Ethics of sham surgery: Perspective of patients. Movement Disorders 23:63–68.
• Goldenberg, I., Moss, A.J., Peterson, D.R., McNitt, S., Zareba,W., Andrews, M.L., Robinson, J.L., Locati, E.H., Ackerman, M.J., Benhorin, J., Kaufman, E.S., Napolitano, C., Priori, S.G., Qi, M., Schwartz, P.J., Towbin, J.A., Vincent, G.M., Zhang, L. (2008). Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital Long QT Syndrome. Circulation 117:2184–2191.
• Goldenberg, I., Moss, A.J., Bradley, J., Polonsky, S., Peterson, D.R., McNitt, S., Zareba, W., Andrews, M.L., Robinson, J.L., Ackerman, M.J., Benhorin, J., Kaufman, E.S., Locati, E.H., Napolitano, C., Priori, S.G., Qi, M., Schwartz, P.J., Towbin, J.A., Vincent, G.M., Zhang, L. (2008). Long QT Syndrome after age 40. Circulation 117:2192–2201.
• Oakes, D. and Peterson, D.R. (2008). Survival methods: Additional topics. Circulation 117:2949-2955.
• DiCenzo, R., Peterson, D.R., Cruttenden, K., Mariuz, P., Rezk, N.L., Hochreiter, J., Gelbard, H., and Schifitto, G. (2008). Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in HIV-infected adults receiving atazanavir/ritonavir. Antimicrobial Agents and Chemotherapy (in press).
• Walsh, E.E., Peterson, D.R., and Falsey, A.R. (2008). Another piece of the puzzle: Human metapneumovirus infection in adults. Archives of Internal Medicine (in press).