Critical Care Research

Fellowship Research

Our faculty and fellows are involved in a wide variety of research pursuits. Examples include Dr. Parilla’s bench career studying pulmonary inflammatory pathways. Dr. Cholette has several active protocols examining coagulation parameters in complex congenital heart disease. Dr.’s Rubenstein and Harmon have funding to develop non-invasive measures of cardiac output and volume measurements in critically ill infants and children.

Publications/Presentations

A selection of recent publications/presentations is listed below:

Gigliotti F., E.L. Crow*, S.P. Bhagwat and T.W. Wright. Sensitized CD8+ T-cells fail to Control Organism Burden but Accelerate the Onset of lung injury during Pneumocystis carinii Pneumonia. Infection and Immunity, Nov. 2006 p. 6310-16.
*Co-first author.
Cholette J, Caserta M, Hardy D, Connolly H. Outcome of Pulmonary Disease-Associated Acute Respiratory Distress Syndrome.
Pediatric Pulmonology in press, accepted November 2006.
Crow EL, Wright TW and F Gigliotti. Exacerbation of Lung Injury as a Consequence of Pneumocystis Carinii-specific Immune Response. Am. J. Respir. Crit. Care Med. 169(7) 2004.
Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production:
implications for therapy of lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1146-53. Epub 2005 Feb.
O’Reilly KMA, Daugherty LE, Sime PJ. Gender specific considerations in Interstital Lung Disease. In: Principles of Gender Specific Medicine. Ed. Legato M. Academic Press 2004 Vol 1:309-316.
Thatcher TH, Burgess HA, Daugherty LE, Redonnet MR, Phipps RP, Sime PJ. PPAR Agonists Inhibit TBF beta-Induced Myofibroblast Differentiation In Vitro and Silica-Induced Pulmonary Fibrosis In Vivo. Am. J. Respir. Crit. Care Med. 169(7) A301, 2004.
Burgess HA, Thatcher TH, Daugherty LE, Redonnet MR, Phipps RP, Sime PJ. Inhibition of Myofibroblast Differentiation In Vitro and Silica-Induced Pulmonary Fibrosis In Vivo by PPAR Agonists. 13th Fibrosis Colloquium (Banff) 2004.
Maffei FA Powers KS, van der Jagt EW, Standage SW, Connolly HV, Harmon WG, Sullivan, JS and JS Rubenstein, MD. 2004. Duration of mechanical ventilation in life-threatening pediatric asthma: Description of an acute asphyxial subgroup. Pediatrics 14(3): 762-7.
Maffei FA, Connolly HV. An unexpected finding on a pediatric chest radiograph. J. Emer Med. 2001. May 20(4):411-2.
Powers KS, Nazarian EB, TapyrikSA, Kohli SM, Yin H, van der Jagt EW, Sullivan JS, Rubenstein JS. Bispectral Index as a Guide for Titration of Propofol During Procedural Sedation Among Children. Pediatrics 2005;115:1666-1674.

Critical Care Research

Critical Care

Division Home