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Subhash C. Juneja, Ph.D.

Research Assistant Professor of Pathology and Laboratory Medicine

Cancer and Developmental Molecular Biology
Phenotypic Analysis

URMC Labs
601 Elmwood Ave., Rm 1-2115
Rochester, NY 14642-8626
Tel: (585) 273-4062
Fax: (585) 756-4468

subhash_juneja@urmc.rochester.edu

Dr. Juneja's current research focus is on the mechanism of Evi1 and its role in leukemogenesis. He is working with Dr. Archibald Perkins on this project.

Qualifications

M.Sc. Animal Physiology, Kurukshetra University, India
Ph.D. Animal Biochemistry, Kurukshetra University, India
Postdoctoral Fellow, University of Western Ontario, London, Ontario, Canada

Research Overview

Previous studies include: Role of Cx43 in heart and gonad development; Cross talk between Wnt and Notch signaling in breast cancer; Role of cell cycle protein, BubR1, in aging and infertility; Mechanisms involved in vesicle sorting and endocytosis using Hrb- and intersectin-transgenic mice.

Publications

Cleary MP, Hu X, Grosssmann ME, Juneja SC, Dogan S, Grande JP, Maihle NJ (2007): Prevention of mammary tumorigenesis by intermittent caloric restriction, does caloric intake during refeeding modulate the response? Experimental Biology and Medicine 232: 70-80.

Juneja SC, van Deursen JM (2005): A mouse model of familial oligoasthenoteratozoospermia. Human Reproduction 20: 881-893.

Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM (2004). BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nature Genetics 36: 744-749.

Cleary MP, Juneja SC, Phillips FC, Hu X, Grande JP, Maihle NJ (2004). Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Experimental Biology and Medicine 229: 182-193.

Cleary MP, Grande JP, Juneja SC, Maihle NJ (2004). Diet-induced obesity and mammary tumor develop- ment in MMTV-neu female mice. Nutrition and Cancer 50: 174-180.

Boerner JL, Danielsen AJ, Lovejoy CA, Wang Z, Juneja SC, Faupel-Badger JM, Darce JR and Maihle NJ (2003): Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis. Oncogene 22: 6679-6689.

Cleary MP, Phillips FC, Getzin SC, Jacobson TL, Jacobson MK, Christensen TA, Juneja SC, Grande JP, Maihle NJ (2003): Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors. Breast Cancer Research and Treatments 77: 205-215.

Juneja SC (2003): mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse. Indian Journal of Physiology and Pharmacology 47: 147-156.

Juneja SC (2002): Development of infertility at young adult age in a mouse model of human Sandhoff disease. Reproduction, Fertility and Development 14: 407-412.

Maihle NJ, Baron AT, Barrette BA, Boardman CH, Christensen TA, Cora EM, Faupel-Badger JM, Greenwood T, Juneja SC, Lee H, Reiter JL, Podratz KC (2002): EGF/ErbB receptor family in ovarian cancer. Cancer Treatment Research 107: 247-258.

Hu X, Juneja SC, Maihle NJ, Cleary MP (2003): Leptin: A growth factor for normal and malignant breast cells and for normal mammary gland development. Journal of National Cancer Institute 95: 171-173 (correspondence).

Hu X, Juneja SC, Maihle NJ, Cleary MP (2002): Leptin: A growth factor for normal and malignant breast cells and for normal mammary gland development. Journal of National Cancer Institute 94: 1705-1711.

Kang-Decker N, Mantchev GT, Juneja SC, McNiven MM, van Deursen JMA (2001): Lack of acrosome formation in Hrb-deficient mice. Science 294: 1531-1533.

Juneja SC, Barr KJ, Enders GC, Kidder GM (1999): Defects in germ cell line and gonads of mice lacking connexin43. Biology of Reproduction 60: 1263-1270.

De Sousa PA, Juneja SC, Caveney S, Houghton FD, Davies TC, Reaume AG, Rossant J, Kidder GM (1997): Normal development of preimplantation mouse embryos deficient in gap junctional coupling. Journal of Cell Science 110: 1751-1758.

Rong H, Tang X-M, Zhao Y, Juneja SC, Fay MF, Williams RS, Chegini N (1997): Post-surgical intraperitoneal exposure to glove powders modulate inflammatory and immune related cytokines production. Wound Repair and Regeneration 5: 89-96.

Naus CC, Bechberger JF, Zhang Y, Venance L, Yamasaki H, Juneja SC, Kidder GM, Giaume C (1997): Altered gap junctional communication, intercellular signaling, and growth in cultured astrocytes deficient in connexin43. Journal of Neuroscience Research 49(5): 528-40.

Juneja SC, Chegini N, Williams RS, Ksander GA (1996): Ovarian intrabursal administration of transforming growth factor ß1 inhibits follicle rupture in gonadotropin-primed mice. Biology of Reproduction 55: 1444-1451.

Reaume A, De Sousa PA, Kulkarni S, Langille BW, Zhu D, Davies T, Juneja SC, Kidder GM, Rossant J (1995): Cardiac malformation in neonatal mice lacking connexin 43. Science 267: 1831-1834.