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Scott A. Kirkley, M.D.

Associate Professor of Pathology and Laboratory Medicine

Blood Banking and Transfusion Medicine
Effects of Allogenic Transfusion on Immune Function

URMC Labs
601 Elmwood Ave., Rm G-1561
Rochester, NY 14642-8608
Tel: (585) 275-5297
Fax: (585) 273-3003

Scott_Kirkley@urmc.rochester.edu

Dr. Kirkley is Associate Director of the Transfusion Medicine Service and Director of the URMC Pathology Residency Training Program. His primary clinical interests include setting up transfusion protocols and helping coordinate laboratory services in support of the organ transplantation programs at Strong Memorial Hospital.

Qualifications

M.D., SUNY Upstate Medical Center 1981
Resident in Internal Medicine, Danbury Hospital, Connecticut 1981-84
Resident in Pathology (AP/CP), New England Deaconess Hospital, Boston 1984-88
Fellow, Transfusion Medicine, Hoxworth Blood Center Univ. of Cincinnati 1988-89
Board Certification, American Board of Internal Medicine 1984
American Board of Pathology (AP/CP) 1989; (Blood Banking) 1990

Research Overview

The suppressive effects of allogeneic (homologous) blood transfusion on the immune system have been recognized for more than twenty years. Along with Dr. Neil Blumberg and others, Dr. Kirkley has been comparing the effects of allogeneic, autologous, and leukoreduced transfusions on immune function.

Publications

Blumberg N, Heal JM, Cowles JW, Hicks GL Jr, Risher WH, Samuel PK, Kirkley SA.Leukocyte-reduced transfusions in cardiac surgery results of an implementation trial. Am J Clin Pathol. 2002 Sep;118(3):376-81.

Kirkley SA and Blumberg N. Chapter 5, Blood Transfusion, in Beaty JH (ed) Orthopaedic Knowledge Update 6. American Academy of Orthopaedic Surgeons, 1999.

Kirkley SA. Proposed mechanisms of transfusion-induced immunomodulation. Clin Diagn Lab Immunol. 1999 Sep;6(5):652-7.

Kirkley SA, Cowles J, Pellegrini VD, Harris CM, Boyd AD, Blumberg N. Blood transfusion and total joint replacement surgery: T helper 2 (TH2) cytokine secretion and clinical outcome. Transfus Med. 1998 Sep;8(3):195-204.

Roberts WA, Kirkley SA, Newby M. A cost comparison of allogeneic and preoperatively or intraoperatively donated autologous blood. Anesth Analg. 1996 Jul;83(1):129-33.

Kirkley SA, Cowles J, Pellegrini VD Jr, Harris CM, Boyd AD, Blumberg N. Cytokine secretion after allogeneic or autologous blood transfusion. Lancet. 1995 Feb 25;345(8948):527.