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W. Richard Burack, M.D., Ph.D.

Associate Professor of Pathology and Laboratory Medicine

Hematopathology
Molecular Mechanisms of Lymphoma Progression

URMC Labs
601 Elmwood Ave., Rm 2-2127
Rochester, NY 14642-8626
Tel: (585) 273-1885
Fax: (585) 276-2390

Richard_Burack@urmc.rochester.edu

Dr. Burack is Director of Hematopathology, including the flow cytometry laboratory and tissue banking activities. He is working to establish an ACGME-accredited hematopathology fellowship program.

Qualifications

Ph.D.. Molecular Biophysics, University of Virginia 1994
M.D., University of Virginia School of Medicine 1995
Resident, Clinical Pathology, University of Virginia Hospital 1995-98
Fellow, Hematopathology, Barnes-Jewish Hospital, St. Louis 1998-99
Board Certification, American Board of Pathology, Clinical Pathology 1998
American Board of Pathology, Hematopathology 2000

Professional Activities

Distinguished Teaching Award, Washington University School of Medicine 2003

Research Overview

Dr. Burack's research interests are membrane phospholipase biology and the T cell immunologic synapse. He is currently studying molecular mechanisms of lymphoma progression in patients.

Publications

Halldorsdottir AM, Zehnbauer BA, Burack WR. Application of BIOMED-2 clonality assays to formalin-fixed paraffin embedded follicular lymphoma specimens: Superior performance of the IGK assays compared to IGH for suboptimal specimens. Leuk Lymphoma. 2007 Jul;48(7):1338-43.

Seo J, Chung YS, Sharma GG, Moon E, Burack WR, Pandita TK, Choi K. Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53. Oncogene. 2005 Dec 8;24(55):8176-86.

Markiewicz MA, Carayannopoulos LN, Naidenko OV, Matsui K, Burack WR, Wise EL, Fremont DH, Allen PM, Yokoyama WM, Colonna M, Shaw AS. Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation. J Immunol. 2005 Sep 1;175(5):2825-33.

Burack WR, Shaw AS. Live Cell Imaging of ERK and MEK: simple binding equilibrium explains the regulated nucleocytoplasmic distribution of ERK. J Biol Chem. 2005 Feb 4;280(5):3832-7. Epub 2004 Nov 16.

Lee KH, Dinner AR, Tu C, Campi G, Raychaudhuri S, Varma R, Sims TN, Burack WR, Wu H, Wang J, Kanagawa O, Markiewicz M, Allen PM, Dustin ML, Chakraborty AK, Shaw AS. The immunological synapse balances T cell receptor signaling and degradation. Science. 2003 Nov 14;302(5648):1218-22. Epub 2003 Sep 25.

Burack WR, Lee KH, Holdorf AD, Dustin ML, Shaw AS. Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J Immunol. 2002 Sep 15;169(6):2837-41.

Hailman E, Burack WR, Shaw AS, Dustin ML, Allen PM. Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity. 2002 Jun;16(6):839-48.

Burack WR, Cheng AM, Shaw AS. Scaffolds, adaptors and linkers of TCR signaling: theory and practice. Curr Opin Immunol. 2002 Jun;14(3):312-6. Review.

Nguyen A, Burack WR, Stock JL, Kortum R, Chaika OV, Afkarian M, Muller WJ, Murphy KM, Morrison DK, Lewis RE, McNeish J, Shaw AS. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol. 2002 May;22(9):3035-45.

Holdorf AD, Lee KH, Burack WR, Allen PM, Shaw AS. Regulation of Lck activity by CD4 and CD28 in the immunological synapse. Nat Immunol. 2002 Mar;3(3):259-64. Epub 2002 Feb 4.

Bromley SK, Burack WR, Johnson KG, Somersalo K, Sims TN, Sumen C, Davis MM, Shaw AS, Allen PM, Dustin ML. The immunological synapse. Annu Rev Immunol. 2001;19:375-96. Review.

Burack WR, Shaw AS. Signal transduction: hanging on a scaffold. Curr Opin Cell Biol. 2000 Apr;12(2):211-6. Review.

Burack WR, Dibble AR, Biltonen RL. The relationship between compositional phase separation and vesicle morphology: implications for the regulation of phospholipase A2 by membrane structure. Chem Phys Lipids. 1997 Nov 19;90(1-2):87-95.

Burack WR, Dibble AR, Allietta MM, Biltonen RL. Changes in vesicle morphology induced by lateral phase separation modulate phospholipase A2 activity. Biochemistry. 1997 Aug 26;36(34):10551-7.

Burack WR, Sturgill TW. The activating dual phosphorylation of MAPK by MEK is nonprocessive. Biochemistry. 1997 May 20;36(20):5929-33.

Burack WR, Gadd ME, Biltonen RL. Modulation of phospholipase A2: identification of an inactive membrane-bound state. Biochemistry. 1995 Nov 14;34(45):14819-28.

Burack WR, Biltonen RL. Lipid bilayer heterogeneities and modulation of phospholipase A2 activity. Chem Phys Lipids. 1994 Sep 6;73(1-2):209-22. Review.

Burack WR, Yuan Q, Biltonen RL. Role of lateral phase separation in the modulation of phospholipase A2 activity. Biochemistry. 1993 Jan 19;32(2):583-9.