Dr. Huang's clinical interests are in oncologic surgical pathology, genitourinary pathology, and Immunohistochemistry. He is the co-director of the GU pathology fellowship program and the director of the clinical immunohistochemistry laboratory.

Qualifications

M.D., Anhui Medical University, China 1983
Ph.D., Molecular Biology, New York University 1991
Postdoctoral Fellow, Pharmacology, New York University 1991-94
Postdoctoral Fellow, Medicine, Yale University 1994-95
Residency in Pathology, New York University 1995-99
Fellow, Oncologic Surgical Pathology, Memorial Sloan Kettering Cancer Center 1999-2000

Research Overview

Dr. Huang's research interests are in the areas of: 1) molecular mechanisms of oncogenesis; 2) neuroendocrine differentiation in prostate cancer and its role in androgen-independent growth of prostate cancer cells. For further details see the Neuroendocrine Prostate web site.

Publications

Markhardt BK, Rubens DJ, Huang J, Dogra VS. Sonographic features of biliary hamartomas with histopathologic correlation. J Ultrasound Med. 2006 Dec;25(12):1631-3.

Oh WK, Tay MH, Huang J. Is there a role for platinum chemotherapy in the treatment of patients with hormone-refractory prostate cancer? Cancer. 2007 Feb 1;109(3):477-86. Review.

Wu C, Huang J. PI3 kinase-AKT-mTOR pathway is essential for neuroendocrine differentiation of prostate cancer. J Biol Chem. 2006 Dec 4; [Epub ahead of print]

Wu C, Na YQ, Yao JL, di Sant'Agnese PA, Huang JT. [Neuroendocrine differentiation in prostate cancer] Zhonghua Bing Li Xue Za Zhi. 2006 Sep;35(9):565-7. Chinese.

Huang J, Yao JL, di Sant'agnese PA, Yang Q, Bourne PA, Na Y. Immunohistochemical characterization of neuroendocrine cells in prostate cancer. Prostate. 2006 Jul 24; [Epub ahead of print]

Zhang Z, Rosen DG, Yao JL, Huang J, Liu J. Expression of p14(ARF), p15(INK4b), p16(INK4a), and DCR2 increases during prostate cancer progression. Mod Pathol. 2006 Jun 23; [Epub ahead of print]

Yao JL, Madeb R, Bourne P, Lei J, Yang X, Tickoo S, Liu Z, Tan D, Cheng L, Hatem F, Huang J, di Sant'Agnese PA. Small cell carcinoma of the prostate: an immunohistochemical study. Am J Surg Pathol. 2006 Jun;30(6):705-712.

Huang J, Yao J, Di Sant'agnese PA. Neuroendocrine differentiation in prostate cancer. In Prostate Cancer: Principles and Practice pp. 143-150. Ed. Kirby R, Partin AW, Feneley M, Parsons JK. Martin Dunitz Ltd (Taylor & Francis Group), London, UK 2006.

Wu C, Zhang L , Bourne PA, Reeder J, Di Sant'agnese PA, Yao JL, Na Y, Huang J . Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer . Prostate. 2006 May 1; [Epub ahead of print].

Lei JY, Bourne PA, Disant'agnese PA, Huang J . Cytoplasmic staining of TTF-1 in the differential diagnosis of hepatocellular carcinoma vs cholangiocarcinoma and metastatic carcinoma of the liver . Am J Clin Pathol. 2006 Apr;125(4):519-525.

Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S. IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. Oncogene. 2005 Oct 24; [Epub ahead of print]

Li H, Zhang L, Lou H, Ding I, Kim S, Wang L, Huang J, Di Sant'Agnese PA, Lei JY. Overexpression of decoy receptor 3 in precancerous lesions and adenocarcinoma of the esophagus. Am J Clin Pathol. 2005 Aug;124(2):282-7.

Huang J, Yao JL, Zhang L, Bourne PA, Quinn AM, di Sant'Agnese PA, Reeder JE. Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer. Am J Pathol. 2005 Jun;166(6):1807-15.

Li R, Ni J, Bourne PA, Yeh S, Yao J, di Sant'Agnese PA, Huang J. Cell culture block array for immunocytochemical study of protein expression in cultured cells. Appl Immunohistochem Mol Morphol. 2005 Mar;13(1):85-90.

Li R, Yao JL, Bourne PA, di Sant'Agnese PA, Huang J. Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinoma. Arch Pathol Lab Med. 2004 Dec;128(12):1412-7.

Yao JL, Bourne PA, Yang Q, Lei J, di Sant'Agnese PA, Huang J. Overexpression of human carcinoma-associated antigen in urothelial carcinoma of the bladder. Arch Pathol Lab Med. 2004 Jul;128(7):785-7.

Liang S, Yao J, Bourne PA, diSant'Agnese PA, Huang J, Lei JY. Overexpression of human carcinoma-associated antigen in esophageal adenocarcinoma and its precursor lesions. Am J Clin Pathol. 2004 Nov;122(5):747-51.

Hu YC, Yeh S, Yeh SD, Sampson ER, Huang J, Li P, Hsu CL, Ting HJ, Lin HK, Wang L, Kim E, Ni J, Chang C. Functional Domain and Motif Analyses of Androgen Receptor Coregulator ARA70 and Its Differential Expression in Prostate Cancer. J Biol Chem. 2004 Aug 6;279(32):33438-46. Epub 2004 May 27.

Patton KT, Tretiakova MS, Yao JL, Papavero V, Huo L, Adley BP, Wu G, Huang J, Pins MR, Teh BT, Yang XJ. Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma. Am J Surg Pathol. 2004 Aug;28(8):1045-1050.

Daiss J, Carney J, Cartun R, Codington J, Erdrich C, Hinchman C, Huang J, Mauck J, Schnipelsky P. Human carcinoma antigen: a marker useful for discriminating between benign prostatic hyperplasia and prostate cancer. J Clinical Ligand Assay 2003; 26: 177-180.

Chen TS, McNally M, Hulbert W, Di Sant'Agnese PA, Huang J. Renal oncocytosis presenting in childhood: a case report. Int J Surg Pathol. 2003 Oct;11(4):325-9.

Ni J, Chen M, Zhang Y, Li R, Huang J, Yeh S. Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. Biochem Biophys Res Commun 2003 Jan 10;300(2):357-63. PubMed Publication List

Lee Y-F, Lin W-J, Huang J, Messing EM, Chan FL, Wilding G, Chang C. Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells. Cancer Res 2002 62:6039-6042. PubMed Publication List

Liu Z, Huang J, Yan Z, Tan J. Application of flow cytometry in the diagnosis and differential diagnosis of lymphoma and leukemia. Chinese J Path 2002 31:352-353.

Huang J. and di Sant'Agnese PA. Neuroendocrine differentiation in prostate cancer: an overview IN Advances in oncology: the expanding role of octreotide I. Ed. SWJ Lamberts and L Dogliotti. BioScientifica Ltd, Bristol, UK 2002 p. 243-262.

Huang J, Behrens C, Wistuba II, Gazdar AF, Jagirdar J. Clonality of combined tumors. Arch Pathol Lab Med. 2002 Apr;126(4):437-41. PubMed Publication List

Huang J, Behrens C, Wistuba I, Gazdar AF, Jagirdar J. Molecular analysis of synchronous and metachronous tumors of the lung: impact on management and prognosis. Ann Diagn Pathol. 2001 Dec;5(6): 321-9. PubMed Publication List

Gu M, Shi W, Huang J, Barakat RR, Thaler HT, Saigo PE. (2000) Association between initial diagnostic procedure and hysteroscopy and abnormal peritoneal washings in patients with endometrial carcinoma. Cancer (Cancer Cytopathology) 90: 143-7. PubMed Publication List

Helpful Links

• Pathology Department Faculty List
• Areas of Excellence - Anatomic Pathology
• Areas of Excellence - Clinical Pathology
• Pathology Ph.D. Program Faculty

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