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Archibald Perkins, M.D., Ph.D.

Professor of Pathology and Laboratory Medicine

Hematopathology
Mechanisms of Leukemogenesis

URMC Labs
601 Elmwood Ave., Rm 1-2102
Rochester, NY 14642-8626
Tel: (585) 276-3399
Fax: (585) 756-4468

Archibald_Perkins@urmc.rochester.edu

Dr. Perkins is an active participant in the clinical hematopathology service as well as a researcher exploring the genes that impact the development of leukemias and other human malignancies. His primary focus is acute myeloid leukemia (AML), a particularly lethal type of cancer with no effective thereapies at present.

Qualifications

M.D., Columbia University College of Physicians and Surgeons 1986
Ph.D., Human Genetics and Development, Columbia University 1987
Resident in Pathology, Brigham and Woman's Hospital 1986-88
Postdoctoral Fellow, Mammalian Genetics Laboratory, NCI-Frederick Cancer Research and Development Center 1988-1992
Board Certification, American Board of Pathology, Anatomic Pathology 1991

Professional Activities

Member, Peer Review Committee for Molecular Genetics and Oncogenes, American Cancer Society 2002-2006
Co-Organizer, International Meeting on Myelopoiesis and Myeloid Leukemia, Annapolis, MD 1995, 1997, 1999, 2001

Research Overview

Dr. Perkins' current research focus is on Evi1, a complex locus that plays a critical role in both normal hematopoesis and myeloid leukemogenesis. Evidence indicates that Evi1 is an important player in maintenance of the leukemic stem cell compartment by increasing proliferation and prolonging survivial, in part through regulation of the transcription factor Gata2 and the anti-apoptotic molecue Bc12a1. His current work encompasses embryogenesis in gentically modified mice, identification of chromosomal Evi1 binding targets, Evi1 protein-protein interactions, clinical implications of chromosomal rearrangements involving Evi1, and exploration of potential therapeutic approaches to block the function of Evi1 in leukemia. See Perkins Lab pages for further info.

Publications

Jackson-Fisher AJ, Bellinger G, Shum E, Duong JK, Perkins AS, Gassmann M, Muller W, Kent Lloyd KC, Stern DF. Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4. Oncogene. 2006 Sep 14;25(41):5664-72. Epub 2006 May 1.

Yatsula B, Galvao C, McCrann M, Perkins AS. Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. Leukemia. 2006 Jan;20(1):162-5. No abstract available.

Boyd KE, Xiao YY, Fan K, Poholek A, Copeland NG, Jenkins NA, Perkins AS. Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR. Blood. 2006 Jan 15;107(2):733-41. Epub 2005 Oct 4.

Yatsula B, Lin S, Read AJ, Poholek A, Yates K, Yue D, Hui P, Perkins AS. Identification of binding sites of EVI1 in mammalian cells. J Biol Chem. 2005 Sep 2;280(35):30712-22. Epub 2005 Jul 8.

Amin DN, Perkins AS, Stern DF. Gene expression profiling of ErbB receptor and ligand-dependent transcription. Oncogene. 2004 Feb 19;23(7):1428-38.

Kluger HM, Kluger Y, Gilmore-Hebert M, DiVito K, Chang JT, Rodov S, Mironenko O, Kacinski BM, Perkins AS, Sapi E. cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model. Lab Invest. 2004 Mar;84(3):320-31.

Chatterjee G, Rosner A, Han Y, Zelazny ET, Li B, Cardiff RD, Perkins AS. Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertion. Am J Pathol. 2002 Dec;161(6):2241-53.

Kone J, Arroyo J, Savinelli T, Lin S, Boyd K, Wu Y, Nimmakayalu M, Copeland NG, Jenkins NA, Qumsiyeh M, Hu P, Prescott A, Wu H, Yang L, Roe B, Perkins AS. F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4. Leukemia. 2002 Sep;16(9):1827-34.

Perkins AS. Functional genomics in the mouse. Funct Integr Genomics. 2002 Aug;2(3):81-91. Epub 2002 Mar 9. Review.

Hui P, Glusac EJ, Sinard JH, Perkins AS. Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). J Cutan Pathol. 2002 Aug;29(7):385-9.

Ma X, Husain T, Peng H, Lin S, Mironenko O, Maun N, Johnson S, Tuck D, Berliner N, Krause DS, Perkins AS. Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA library. Blood. 2002 Aug 1;100(3):833-44.

Wysolmerski JJ, Dann PR, Zelazny E, Dunbar ME, Insogna KL, Guise TA, Perkins AS. Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis. J Bone Miner Res. 2002 Jul;17(7):1164-70.