Department Of Medicine

Faculty Publications

URMC • Department Of Medicine • Allergy / Immunology & Rheumatology

Allen Anandarajah , MD

Anandarajah, AP, Totterman, S Schwarz EM and Ritchlin, CT. The effect of etanercept on osteoclast precursor frequency and enhancing bone marrow edema in patients with psoriatic arthritis. in press.

Reddy SM, Reed G, Anandarajah, AP, et al. Comparative analysis of disease activity, radiographic features and bone density in psoriatic and rheumatoid arthritis. Arthritis Rheum. in press.

Anandarajah AP,Ritchlin CT. Infliximab in psoriatic arthrits. Future Rheumatology. in press.

Anandarajah AP, Schwarz EM: Anti-RANKL therapy for inflammatory bone disorders: mechanisms and potential clinical applications. J Cell Biochem. 2006; 97 (2): 226-32.

Anandarajah AP, Ritchlin CT Update on the treatment of spondyloarthropathies. Curr Opin Rheum 2005;(May) 17: 247-256.

Anandarajah AP, Ritchlin CT. Pathogenesis of Psoriatic Arthritis. Curr Opin Rheum 2004; 16: 338-343.

Anandarajah AP, Schwarz EM. Dynamic exercises in patients with rheumatoid arthritis. Annals Rheum Disease 2004. (Nov) 63 (11).

Anandarajah AP, Ritchlin CT. Update on the treatment of Spondyloarthropathy. Treatment update on Spondyloarthropathy. From NSAIDs and DMARDs to anti-TNF agents. Postgrad Medicine 2004; 116: 31-40.

Anandarajah A, Ritchlin CT. Etanercept in psoriatic arthritis. Expert Opinion Biol. Ther . 3(1):169-177, 2003

Jennifer Anolik, MD, PhD

Shinnar AE, Anolik JH, Johnson DA, and Lobl TJ. Physical and conformational properties of a synthetic leader peptide from bovine serum albumin. Proceedings of the Eleventh American Peptide Symposium, 1990.

Anolik JH, Klinge CM, Bambara RA, and Hilf R. Differential impact of flanking sequences on estradiol-vs 4-hydroxytamoxifen-liganded estrogen receptor binding to estrogen responsive element DNA. J. Steroid Biochem Molec. Biol. 46: 713-730, 1993.

Anolik JH, Klinge CM, Hilf R, and Bambara RA. Cooperative binding of estrogen receptor to DNA depends on spacing of binding sites, flanking sequence, and ligand. Biochemistry 34: 2511-2520, 1995.

Anolik JH, Klinge CM, Brolly C, Bambara RA, and Hilf R. Stability of the ligand-estrogen receptor interaction depends on estrogen response element flanking sequences and cellular factors. J. Steroid Biochem Molec. Biol. 59: 413-429, 1996

Sathya G, Li W, Klinge CM, Anolik JH, Hilf R, and Bambara RA. Effects of multiple estrogen responsive elements, their spacing, and location on estrogen response of reporter genes. Mol. Endo. 11: 1994-2003, 1997.

Anolik JH, DiGiovanna JJ, and Gaspari AA. Effect of isotretinoin therapy on natural killer cell activity in patients with xeroderma pigmentosum. Br. J. of Derm. 138: 236-241, 1998.

Anolik JH and Ritchlin C. A 40 year old woman with destructive arthritis and severe interstitial lung disease, AML Interactions, 2000.

Anolik JH, Snider J, and Francis C. Post-transfusion purpura secondary to an alloantibody reactive with HPA-5a (Brb), Transfusion 41(5): 633, 2001.

Anolik JH, Wildy K, Cohn S, Marquart J, Totterman S, and Zwillich S. Multifocal staphylococcus aureus infection originating from the sacroiliac joint in a rheumatoid arthritis patient, J. Rheumatology 28: 217-220, 2001.

Anolik JH, Campbell D, Felgar R, Young F, Sanz I, Rosenblatt J, and Looney RJ. The relationship of FcgRIIIa genotype to the degree of B cell Depletion by Rituximab in the treatment of SLE, Arthritis and Rheumatism 48(2): 455, 2003

Anolik JH, Looney RJ, Bottaro A, Sanz I, and Young F. Down-regulation of CD20 on B cells with CD40 activation, Eur J Imm 33(9): 2398-2409, 2003.

Anolik JH, Sanz I, and Looney J. B cell depletion therapy in SLE (Rituximab). Current Rheumatology Reports 5: 350-356, 2003.

Cappione AJ, Pugh-Bernard AE, Anolik JH, and Sanz I. Lupus VH4.34-encoded antibodies bind to a 220 kDa glycoform of CD45 (B220) on the surface of human B lymphocytes, J Immunology 172: 4298, 2004.

Looney RJ, Anolik JH, Campbell D, Felgar RE, Young F, Sloan J, Rosenblatt J, Sanz I. B cell depletion as a novel treatment for SLE, Arthritis and Rheumatism 50:2580, 2004

Anolik JH, Barnard J, Cappione A, Pugh-Bernard, A, Young F, Sanz I, and Looney J. Rituximab improves peripheral B cell abnormalities in human SLE, Arthritis and Rheumatism 50:3580, 2004.

Looney RJ, Anolik JH, Sanz I. B lymphocytes in SLE: Lessons from therapy targeting B cells, Lupus, 13: 1-10, 2004.

Looney RJ, Anolik JH, Campbell D, Felgar RE, Young F, Arend LJ, Sloand JA, Rosenblatt J, Sanz I. B Cell Depletion as a Novel Treatment for Systemic Lupus Erythematosus: A Phase I/II Dose-escalation Trial of rituximab. Arthritis and Rheumatism. 50(8):2580-9, 2004.

Looney RJ, Anolik JH, Sanz I. B cells as therapeutic targets for rheumatic diseases, Current Opinion in Rheumatology 16: 180, 2004.

Milner, E.C., Anolik, J., Cappione, A., and Sanz, I. Human innate B cells: a link between host defense and autoimmunity? Springer Semin Immunopathol 26:433-452, 2005.

Sanz I, Anolik J. Reconstitution of the adult B cell repertoire after treatment with rituximab. Arthritis Res Ther. 7(5):175, 2005

Anolik JH, Aringer M. New treatments for SLE: cell-depleting and anti-cytokine therapies. Best Pract Res Clin Rheumatol. 19(5):859, 2005

Cappione AJ, Anolik JH, Pugh-Bernard AE, Barnard J, Dutcher P, Silverman G, and Sanz I. Germinal center exclusion of autoreactive B cells is defective in human SLE, Journal of Clinical Investigation 115: 3205, 2005.

Looney RJ, Anolik JH, Sanz I. New therapies for systemic lupus erythematosus: cellular targets. Rheum Dis Clin North Am 32:201-215, 2006

Anolik JH, Friedberg J, Barnard J, Owen T, Cushing E, Campbell D, Kelly J, Looney RJ, Fisher RI, Sanz I. B cell reconstitution after rituximab recapitulates B cell ontogeny, Clinical Immunology, in press, 2006.

Sabahi R and Anolik JH. B cell targeted therapy for systemic lupus erythematosus. Drugs 66:1, 2006.

Anolik JH, Barnard J, Owen T, Zheng B, Kemshetti S, Looney RJ, Sanz I. Recovery of peripheral blood memory B cells after rituximab treatment in SLE is delayed and lags behind lymphoid tissue memory B cell reconstitution, manuscript submitted 2006.

Anolik JH, Barnard J, Zheng B, Owen T, Quach T, Wei C, Miyake B, Milner E, Looney RJ, Sanz I. Heterogeneity in human transitional B cells revealed by B cell depletion therapy, manuscript submitted 2006.

Anolik JH, Ravikumar R, Barnard J, Owen T, Cushing E, Kemshetti S, Milner ECB, Dutcher P, Hadley J, Sanz I. Anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid follicular dendritic cell networks, manuscript in preparation.

John Baum, MD

Baum J. Aspirin. In: Update in Rheumatology. CDROM, 2002.

Baum J. Rheumatoid Arthritis In: Encyclopedia of Public Health. L. Breslow ed. Macmillan Reference USA Publishers; 2001.

Siegel DM, Baum J. In: Adolescent Rheumatology. D. Isenberg D and J.J. Miller eds. Martin Dunit Publishers, London, 1999

Andrea Bottaro, Ph.D.

Kuzin II, Ugine GD, Barth RK, Shultz LD, Nahm MH, Young FM, Bottaro A.A new murine model of humoral immuno-deficiency specifically affects classswitching to T-independent antigens. Eur J Immunol. 2004, 34(7):1807-16.

Filatov AV, Shmigol IB, Kuzin II, Sharonov GV, Feofanov AV.Resistance of cellular membrane antigens to solubilization with Triton X-100 as amarker of their association with lipid rafts-analysis by flow cytometry. J Immunol Methods. 2003, 278(1-2):211-9.

Kuzin II, Snyder JE, Ugine GD, Wu D, Lee S, Bushnell T Jr, Insel RA, Young FM,Bottaro A. Tetracyclines inhibit activated B cell function. Int Immunol. 2001 (7):921-31

Kuzin I, Ugine G, Wu D, Young F, Chen J, Bottaro A. Normal isotype switching in B cells lacking the I? exon splice donor site: evidence for multiple I?-like transcripts. J Immunol 164, 1451-1457, 2000

Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S., Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc Natl Acad Sci USA 97, 3336-3341, 2000.

Kuzin, I, Snyder J, Ugine G, Wu D, Lee S, Bushnell T, Insel R, Young F, Bottaro A. Tetracyclines inhibit activated B cell function, Int. Immunol. 12, 921-931, 2001.

Sakai E, Bottaro A, Alt FW. The immunoglobulin heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination. Int Immunol 11, 1709-1713, 1999.

Brusco A, Saviozzi S, Cinque F, Bottaro A, DeMarchi M. A recurrent breakpoint in the most common deletion of the Ig heavy chain locus (del A1-GP-G2-G4-E). J Immunol 163, 4392-4398, 1999

Luojing Chen, Ph.D.

Chen, L., Zhou, L., Cen, Y. (1986) Transposon Tn5 mutagenesis in Bradyhizobium Japonicum. Acta Microbiologica Sinica, 26, 321-325.

Chen, L, Ford C. and Nikolov, Z. (1991) Adsorption to starch of a b-galactosidase fusion protein containing the starch-binding region of Aspergillus glucoamylase. Gene. 99,121-126.

Chen, L., Ford, C. Kusanadi, A. and Nikolov, Z. (1991) Improved adsorption to starch of a b-galactosidase fusion protein containing the starch-binding domain from Aspergillus glucoamylase. Biotech. Progress. 77, 225-229.

Chen, L., Kosslak, R. and Atherly, A. (1994) Mechanical shear of high molecular weight DNA in agarose plugs. BioTechniques. 16,228-229.

Chen, L., Ford, C. and Nikolov, Z. (1995) Deletion analysis of starch-binding domain of Aspergillus glucoamylase in Saccharomyces cerevisiae. Protein Engineering. 8,1049-1055.

Chen, L., Moon, Y. and Atherly, A. (1995) Cloning and sequencing of stearyol-ACP desaturase gene from soybean. Plant Physiol. 109, 1498-1501.

Chen, L., Kim, T.J., and Pillai, S. (1998) Inhibition of caspase activity prevents anti-IgM induced apoptosis but not ceramide generation in WEHI 231 B cells. Mol. Immunol. 35,195-205.

Chen, L., Haider, K.; Cariappa, A.; Rowitch, D. and Pillai, S. (2001) PKC associated kinase (PKK), a novel membrane-associated, ankyrin repeat containing protein kinase. J. Biol. Chem. 276(24): 21737-21744.

Moran ST, Haider K, Ow Y, Milton P, Chen L, Pillai S. (2003) Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner. J Biol Chem. 13; 278(24): 21526-33.

Cariappa A, Chen L, Haider K, Tang M, Nebelitskiy E, Moran ST, Pillai S. (2003). A catalytically inactive form of protein kinase C-associated kinase/receptor interacting protein 4, a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with early B cell development. J Immunol. 15;171(4): 1875-80.

Lee SC, Bottaro A, Chen L, Insel RA. Mad1 is a transcriptional repressor of Bcl-6. Mol Immunol. (2006) 43(12): 1965-71.

Kim SW, Oleksyn DW, Rossi RM, Jordan Craig, Sanz I, Chen ,L , Zhao J. (2008). Protein kinase C-associated kinase is required for NF-{kappa}B signaling and survival in diffuse large B-cell lymphoma cells. Blood.,111(3): 1644-1653.

James Kobie, Ph.D.

Hamalainen-Laanaya, H.K., Kobie, J.J., Chang, C., and Zeng, W.P. Temporal and Spatial Changes of Histone 3 K4 Dimethylation at the IFN-{gamma} Gene during Th1 and Th2 Cell Differentiation. J Immunol. 179, 6410-6415 (2007).

Kobie, J. J., Shah, P.R., Yang, L., Rebhahn, J.A., Fowell, D.J., and Mosmann, T.R.. T regulatory and primed uncommitted CD4 T cells express CD73 which suppresses effector CD4 T cells by converting 5’AMP to adenosine. J Immunol. 177, 6780-6 (2006)

Zaiss, D.M., Yang, L., Shah, P., Kobie, J.J., Urban, J.F., and Mosmann, T.R. Amphiregulin - a Th2 cytokine important for nematode resistance. Science. 314, 1746 (2006)

Han T, Alverez I, Kobie JJ,Ramanathapuiam L, Dial S, Fulton A, Besselsen D, Walker E, Akporiaye ET. Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer. Int J Cancer. 118, 2220-31 (2006)

Yang, L., Kobie, J.J., and Mosmann, T.R.. CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from Type 1 or Type 2 effector cells. J Immunol. 161, 6458-6464 (2005)

Ramanathapuram, L.V., Kobie, J.J., Bearss, D., Payne, C.M., Trevor, K.T., and Akporiaye, E.T.. alpha-tocopheryl succinate sensitizes established tumors to vaccination with nonmatured dendritic cells. Cancer Immunol Immuother. 53, 580-588 (2004)

Kobie, J. J., Wu, R. S., Kurt, R. A., Lou, S., Adelman, M. K. , Whitesell, L. J., Ramanathapuram, L. V., Arteaga, C. L., and Akporiaye, E. T.. TGF-b inhibits the antigen presenting functions and anti-tumor activity of dendritic cell vaccines. Cancer Research. 63, 1860-1864 (2003)

Kobie, J. J., and Akporiaye, E. T.. Immunosuppressive Role of Transforming Growth Factor –Beta in Breast Cancer. Clinical and Applied Immunology Reviews. 3, 277-287 (2003)

Wu, R. S., Kobie, J. J., Besselsen, D. G., Fong, T. C., Mack, V. D., McEarchern, J. A., and Akporiaye, E. T.. Comparative analysis of IFN-g, B7.1, and antisense TGF-b gene transfer on the tumorigenicity of a poorly immunogenic metastatic mammary carcinoma. Cancer Immunology and Immunotherapy 50, 229-240 (2001).

McEarchern, J. A., Kobie, J. J., Mack, V. D., Wu, R. S., Meade-Tollin, L., Arteaga, C .L., Dumont, N., Besselsen, D., Seftor, E., Hendrix, M. J., Katsanis, E., and Akporiaye, E. T.. Invasion and metastasis of a mammary tumor involves TGF-b signaling. International Journal of Cancer 91, 76-82, (2001).

Kobie, J. J., Peto, J., and Prentice, M.. Toughness response of electrodes within arc furnace cycling. Materials Evaluation 52, 350-354 (1994).

Igor Kuzin, Ph.D.

Kuzin II, Snyder JE, Ugine GD, Wu D, Lee S, Bushnell T Jr, Insel RA, Young FM,Bottaro A. Tetracyclines inhibit activated B cell function. Int Immunol. 2001 (7):921-31

Kuzin II, Ugine GD, Wu D, Young F, Chen J, Bottaro A. Normal isotype switching in B cells lacking the I mu exon splice donor site:evidence for multiple I mu-like germline transcripts. J Immunol. 2000, 164(3):1451-7

John Leddy, MD

Popescu, N.A., Sheehan, M.G., Kouides, P.A., Loughner, J.E., Condemi, J.J., Looney, R.J., and Leddy, J.P. Allergic Reactions To Cyclophosphamide: Delayed Clinical Expression Associated With Positive Immediate

Skin Tests To Drug Metabolites In Five Patients. Journal of Allergy & Clinical Immunology 97(1):26-33, 1996.

Wang, X., Fleischer, D.T., Whitehead, W.T., Haviland, D.L., Rosenfeld, S.l., Leddy, J.P., Snyderman, R., and Wetsel, R.A. Inherited Human Complement C5 Deficiency. Nonsense Mutations In Exons 1 (Gln1 To Stop) And 36 (Arg1458 To Stop) And Compound Heterozygosity In Three African-American Families. Journal of Immunology 154(10):5464-5471, 1995.

Leddy, J.P., Wilkinson, S.L., Kissel, G.E., Passador, S.T., Falany, J.L., and Rosenfeld, S.I. Erythrocyte Membrane Proteins Reactive With IgG (Warm-Reacting) Anti-Red Blood Cell Autoantibodies: II. Antibodies Coprecipitating Band 3 And Glycophorin A. Blood 84(2):650-656, 1994.

Kafka, S.P., Condemi, J.J., Marsh, D.O., and Leddy, J.P. Mononeuritis Multiplex And Vasculitis. Association With Anti-Neutrophil Cytoplasmic Autoantibody. Archives of Neurology 51 (6):565-568, 1994.

R. John Looney, MD

Looney, R., Anolik, J., and Sanz, I. Treatment of SLE with Anti-CD20 Monoclonal Antibody. Curr Dir Autoimmun 8:193, 2005.

Ping Li, MS, Edward M. Schwarz, PhD, Regis J. O’Keefe, MD, PhD, Lin Ma, MS, R. John Looney, MD, Christopher T. Ritchlin, MD, Brendan F. Boyce, MD, and Lianping Xing, PhD. Systemic TNFa mediates an increase in peripheral CD11bhi osteoclast precursors in TNFa transgenic mice. Arthritis & Rheumatism. 50(1):265-76, 2004.

Claus AM, Totterman SM, Sychterz CJ, Tamez-Peña JG, Looney RJ, Engh CA Sr. Computed Tomography to Assess Pelvic Lysis After Total Hip Replacement. Clinical Orthopaedics and Related Research. 422:167-74, 2004.

Joshi S, Scott G, Looney RJ. A successful challenge in a patient with vancomycin-induced linear IgA dermatosis. Annals of Allergy, Asthma & Immunology. 93(1):101-3, 2004.

Looney RJ, Anolik JH, Campbell D, Felgar RE, Young F, Arend LJ, Sloand JA, Rosenblatt J, Sanz I. B Cell Depletion as a Novel Treatment for Systemic Lupus Erythematosus: A Phase I/II Dose-escalation Trial of rituximab. Arthritis and Rheumatism. 50(8):2580-9, 2004.

Anolik JH, Barnard J, Cappione A, Pugh-Bernard, Looney RJ, Sanz I. Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus. Arthritis and Rheumatism. 50(11):3580-90, 2004.

Anolik JH, Barnard J, Cappione A, Pugh-Bernard, A, Young F, Sanz I, and Looney J. Rituximab improves peripheral B cell abnormalities in human SLE, Arthritis and Rheumatism 50:3580, 2004.

Looney RJ, Anolik JH, Campbell D, Felgar RE, Young F, Sloan J, Rosenblatt J, Sanz I. B cell depletion as a novel treatment for SLE, Arthritis and Rheumatism 50:2580, 2004

Li, Schwarz EM, O’Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce FB, and Xing L. (2003) Systemic TNF? promotes erosive joint destruction by increasing CD11bhi osteoclast precursors in the periphery via inducing their mobilization from the bone marrow. Arthritis Rheum 50(1):265-276, 2004.

Anolik JH, Campbell D, Felgar RE, Young F, Sanz I, Rosenblatt J, Looney RJ. The Relationship of FcgRIIIa genotype to Degree of B cell Depletion by Rituximab in the treatment of SLE. Arthritis and Rheumatism 48(2):455-9, 2003.

Anolik J, Looney RJ, Bottaro A, Sanz I, Young F. Down-regulation of CD20 on B cells upon CD40 activation. European Journal of Immunology: 33: 2398-2409, 2003 5548.

Schwarz, E. M., D. Campbell, S. Totterman, A. Boyd, R. J. O'Keefe, and R. J. Looney. 2003. Use of Volumetric Computerized Tomography as a Primary Outcome Measure to Evaluate Drug Efficacy in the Prevention of Periprosthetic Osteolysis: A 1-Year Clinical Pilot of Etanercept vs Placebo. This manuscript won the Orthopedic Research Societies Harris Award 2003. J. Ortho. Res. 21(6):1049-55, 2003

Anolik JH, Campbell D, Felgar R, Young F, Sanz I, Rosenblatt J, and Looney RJ. The relationship of FcgRIIIa genotype to the degree of B cell Depletion by Rituximab in the treatment of SLE, Arthritis and Rheumatism 48: 455, 2003.

Anolik JH, Looney RJ, Bottaro A, Sanz I, and Young F. Down-regulation of CD20 on B cells with CD40 activation, Eur J Imm 33(9): 2398-2409, 2003.

Anolik, J, Sanz, I, Looney, J. B-cell depletion therapy in SLE. Current Rheumatology Reports 5:350, 2003.

Looney RJ, Boyd A, Totterman S, Seo G, Tamez-Pena J, Campbell D, Novotny L, Olcott C, Martell J, Hayes FA, O'Keefe RJ, Schwarz EM. Volumetric CT as a Measurement of Periprosthetic Acetabular Osteolysis and its Correlation with Wear. Arthritis Research. 4(1):59-63, 2002

Looney, RJ, Falsey AR, Walsh E, Campbell D. Effect of Aging on the Cellular Immunity to RSV. Journal of Infectious Diseases. 185(5):682-5, 2002 Mar 1.

Looney RL, Hasan, MS, Coffin D, Campbell D, Falsey AR, Kolassa J, Agosti JM, Abraham GN, Evans TG. Hepatitis B Immunization of Healthy Elderly Adults: Relationship between Naïve CD4+ T Cells and Primary Immune Response, and Evaluation of GM-CSF as an Adjuvant. Clinical Immunology. 21(1):30-6, 2001

Police P.F., Rosier R.N., Looney R.J., Puzas J.E., Schwarz E.M., O'Keefe R.J. Oral Pentoxifylline Inhibits the Release of Tumor Necrosis Factor Alpha from Human Peripheral Blood Monocytes: A Potential Treatment for Aseptic Loosening. Journal of Bone and Joint Surgery. 83: 1057-61, 2001.

Falsey A.R., Walsh E.E., Francis C.W., Looney R.J., Hall W.J., Abraham G.N. Acute Phase Response of C reactive Protein (CRP) and Serum Amyloid A (SAA) to Influenza A Infection in Older Adults. Journal of Infectious Diseases. 183(7):995-9, 2001

Hasan MS, Kallas EG, Thomas EK, Looney RJ, Campbell M, Evans TG. Effects of interleukin-15 on in vitro human T cell proliferation and activation. J Interferon & Cytokine Research 20(2):119-23, 2000.

Frances Lund, Ph.D.

Troy Randall, Ph.D.

Christopher Ritchlin, MD

Ritchlin C., Winchester R. Potential mechanisms for coordinate gene activation in the rheumatoid synoviocyte: implications and hypotheses. Springer Seminars in Immunopath, 11:219-234,1989.

Bucala R., Ritchlin C.T., Winchester R., Cerami A. Constitutive production of mitogenic cytokines by cultured rheumatoid but not osteoarthritic synovial fibroblasts. J Exp Med 173:569-574, 1991.

Konttinen Y.T., Lindy O., Suomalalinen K., Sarri H., Vauhkonen M., Ritchlin C.T., Lauhio A., Santavirta S., Sorsa T. Substrate specificity and activation mechanisms of collagenase from human rheumatoid synovium. Matrix Coll. Rel. Res. Vol. 11:395-403, 1991.

Porges A., Beattie S., Ritchlin C., Kimberly R., Christian C. Patients with systemic lupus erythematosus at risk for pneumocystis carinii pneumonia. J Rheum 19(8):1191-1194, August 1992.

Ritchlin C., Chabot R., Roubey R., Dwyer E., Eberle M., Sulkowicz K., Buyon J., Belmont H., Abramson S. Quantitative EEG in patients with systemic lupus erythematosus and neuropsychiatric dysfunction. Arth Rheum 35(11):1330-1342, 1992.

Sorsa T., Konttinen Y.T., Lindy O., Ritchlin C., Saari H., Suomalainen D., Eklund K.K., Santavirta S. Collagenase in synovitis of rheumatoid arthritis. Sem Arth Rheum 22(1):44-53, 1992.

Rose S., Konttinen Y., Sorsa T., Lindy O., Saari H., Choi S., Törnwall J., Teronen O., Ritchlin C. Tissue distribution and inflammatory regulation of synovial collagenase. Progress in Rheumatology, Vol. 1, 21-25, 1993.

Winchester R, Su F, Ritchlin C. Alteration of synoviocytes by inflammation—the source of a persistent non-immunologic drive in synovitis: analysis of levels of mRNA expression by a simple multi-gene assay. Clinical & Exp Rheum, 11 Suppl 8:S87-90, 1993 Mar-Apr.

Hogan M., Sherry B., Ritchlin C., Fabre M., Winchester R., Cerami A., Bucala R. Differential expression of the small inducible cytokines GRO and GRO by snyovial fibroblasts in chronic arthritis: possible role in growth regulation. Cytokine, Vol 6 (1): 61-69, January 1994.

Ritchlin C., Dwyer E., Stuchin S., Winchester R. Patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from patients with inflammatory and non-inflammatory synovitis. Scan J Immun 40:292-298, 1994.

Ritchlin C. Alternative pathways of inflammation in rheumatoid arthritis. Clinical ImmunolNewsletter 16(4) 57-62, 1996.

Ritchlin C, Haas-Smith S, Hicks D, Osterland K, Looney J. Patterns of cytokine production in psoriatic synovium. J Rheumatol 25(8):15-44-1552, 1998.

Ritchlin C, Haas-Smith SA, Hicks D, Cappuccio J. Osterland CK, Looney RJ. Patterns of cytokine production in psoriatic synovium. J Rheumatol. 1998;25:1544-1552.

Ritchlin C. The synovial fibroblast as an effector cell in inflammatory arthritis. Arthritis Res and Therapy; 2:356-360, 2000.

Ritchlin C, Haas-Smith S. Expression of IL-10 mRNA and protein by synovial fibroblastoic cells. J Rheumatol 28(4); 2001.

Ritchlin C. The pathogenesis of p soriatic arthritis. J Musculoskel Med. 18(5):S37-S44;2001.

Zeltser R, Valle T, Tanck C, Holyst MM, Ritchlin C, Gaspari A. Clinical, Histologic and Immunophenotypic Characteristics of Injection Site Reactions Associated with Etanercept- a Recombinant Tumor Necrosis Factor-α receptor: Fc Fusion Protein. Dermatology. 137(7):893-9, 2001.

Ritchlin CT. Section Editor, Spondyloarthropathies. Current Rheum Reports 3(5):399-404, 2001.

Ritchlin C, Daikh B. Recent Advances in the treatment of spondyloarthropathies. Current Rheum Reports 3(5):399-404, 2001.

Daikh BE, Ritchlin CT. Pseudoxanthoma Elasticum masquerading as Sjogren’s Syndrome. J Clin Rheumatology 8(2):89-93, 2002.

Daikh B, Ritchlin CT. New therapies in rheumatoid arthritis. Clinical Researcher 2(8):15-20, 2002.

Anandarajah A, Ritchlin CT. Etanercept in psoriatic arthritis. Expert Opinion in Pharmacotherapy. 3(1):169-177, 2003

Ritchlin CT. Section Editor, Spondyloarthropathies. Current Rheum Reports. 4(6):498-532, 2002.

Ritchlin CT. Update on clinical trials for spondyloarthopathies. Current Rheum Reports. 4(6): 497, 2002 .

Ritchlin C, Haas-Smith S, Stroyer B, Schwarz E. Mechanisms of TNF-α and RANKL mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest 111(6):821-833, 2003.

Ritchlin CT. Advances in the treatment of psoriatic arthritis: Effects of TNF inhibitors. J Musculoskeletal Med March S13-S-20, 2003.

Vaz A, Barton J, Ritchlin CT. Psoriatic Arthritis. Int J of Adv in Rheum. Fall 2003. 236-246.

Li, Schwarz EM, O’Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce FB, and Xing L. (2003) Systemic TNFa promotes erosive joint destruction by increasing CD11bhi osteoclast precursors in the periphery via inducing their mobilization from the bone marrow. Arthritis Rheum 50(1):265-276, 2004.

Gladman DD, Helliwell P, Mease PJ, Nash P, Ritchlin C, Taylor W. Assessment of Psoriatic Arthritis : A Review of Currently Available Measures. Arthritis Rheum 50(1) :24-35, 2004

Ritchlin CT. Section Editor, Seronegative Arthritis. Current Rheumal Rep. 6(2) 95-125, 2004.

Ritchlin CT. Clinical trials update: Anti-TNF agents in ankylosing spondylitis. Current Rheumatol Rep 6(2): 95-97, 2004.

Ritchlin CT, Schwarz EM, Looney JR. RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis. J Neural and Molecular Interactions J Musculoskeletal Interact . 2004;4(3):276-84.).

Ritchlin CT. Section Editor, Psoriatic Arthritis. Current Rheumol Rep. 6(4):290-1.

Anandarajah A, Ritchlin CT. Pathogenesis of Psoriatic Arthritis. Current Opinion in Rheum 16:338-343, 2004.

Ritchlin, CT. Treatment of psoriasis with intramuscular alefacept. Curr Rheumatol Rep. 2004 Aug;6(4):290-1.

Ritchlin, CT Etanercept monotherapy in psoriasis. Curr Rheumatol Rep.2004 Aug;6(4):290-1.

CT Ritchlin, Efalizumab therapy in plaque psoriasis. Curr Rheumatol Rep. 2004 Aug;6(4):289-91

Ritchlin CT. Comparison of methotrexate and cyclosporine therapy in psoriasis.
Curr Rheumatol Rep. 2004 Aug;6(4):289, 291

Ritchlin CT. Mechanisms of erosion in rheumatoid arthritis. J Rheum 31(7):1229-1237, 2004.

Anandarajah AP, Ritchlin CT. Treatment update on spondyloarthropathy. From NSAIDs and DMARDs to anti-TNF-alpha agents. Postgrad Med. 2004 Nov;116(5):31-6, 39-40..

Veale D, Ritchlin C, FitzGerald O. Immunopathology of psoriasis and psoriatic arthritis. Ann Rheum Dis 64 (Suppl II):ii26 – ii29, 2005.

Gladman D, Ritchlin C, Helliwell P. Psoriatic arthritis clinical registries and genomics. Ann Rheum Dis 64 (Suppl II): ii103 – ii105, 2005.

Ritchlin C. Discussion: Immunology, cellular pathology, genetics. Ann Rheum Dis 64 (Suppl II): ii40 – ii41, 2005.

Anandarajah A, Ritchlin CT. Treatment update on spondyloarthropathy. Curr Opin Rheumatol. 2005 May;17(3):247-56.

Ritchlin CT. Doxycycline in undifferentiated spondyloarthropathy. Curr Rheumatol Rep. 2005 Jun;7(3):171-2

Ritchlin CT. Treatment of reactive arthritis with azithromycin. Curr Rheumatolol Rep. 2005 Jun;7(3):171

Ritchlin CT. Pathogenesis of psoriatic arthritis. Curr Opin Rheumatol. 2005 Jul;17(4):406-12.

Mease PJ, Gladman DD, Ritchlin CT, Ruderman EM, Steinfeld, SD, Choi EH, Sharp JT, Ory PA, Perdok RJ, Weinberg MA; Adalimumab Effectiveness in Psoriatic Arthritis Trial Study Group; Adalimumab for the treatment of patients with moderately to severely active psoriatic arthritis: results of a double-blind, randomized, placebo-controlled trial. Arth Rheum. 2005 Oct;52(10):3279-89.

Gladman DD, Mease PJ, Krueger G, van der Heidje DM, Antoni C, Helliwell PS, Kavanaugh AF, Nash P, Ritchlin CT, Strand CV, Taylor W, Outcome measures in psoriatic arthritis. J Rheumatol. 2005 Nov;32(11):2262-9.

Batliwalla FM, Li W, Ritchlin CT, Xiao X, Brenner M, Laraquione T, Shao T, Durham R, Kemshetti S, Schwarz E, CJoe R, Kern M, Baechler EC, Behrens TW, Gregersen PK, Galko PS. Microarray analyses of peripheral blood cells identifies unique gene expression signature in psoriatic arthritis. Molec Med 2005: Jan-Dec;11(1-12):21-9.

Ritchlin CT. Newer therapeutic approaches: spondyloarthritis and uveitis. Rheum Clin N.A. 2006; 32(1):75-90.

Schwarz EM,Looney RJ, Drissi MH,O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT, . Autoimmunity and bone. Ann NY Acad Sci. 2006 Apr;1068:275-83.

Ritchlin CT. Enthesitis: A Systematic Review. J Rheumatol 2006 Jul;33(7):1435-8.

Kavanaugh A, Ritchlin CT et al. Systematic Review of Treatments for Psoriatic Arthritis: Evidenced-basedApproachand Basis for Treatment Guidelines. J Rheumatol 2006 Jul;33(7):1417-21.

Ritchlin CT, Maksymowych W. Clinical Trials Report. Curr Rheumatol Rep. 2006 Jul;8(4):253-255.

Kleiner A, Ritchlin, CT. Psoriatic Arthritis: Making a Difficult Diagnosis. J Musculoskel Med. August 2006:1206-1218.

Ritchlin CT.. The efficacy and safety of adalimumab in psoriatic arthritis. Curr Rheumatol Rep 2006 8(5):329-331.

Ritchlin CT. The efficacy and safety of infliximab for the treatment of psoriatic arthritis. Nat Clin Pract Rheumatol. 2006;8(5):329-31.

Mallbris L, Ritchlin CT, Stahle, M. Metabolic Disorders in Patients with Psoriasis and Psoriatic Arthritis. Curr Rheum Reports 2006 8(5):355-363.

Ritchlin CT, Maksymowych, M. MRI outcomes in AS after two years of etanercept therapy. Curr Rheumatol Rep 2006;8(4):253-4.

Tausk F, Ritchlin CT. A Medical Conundrum: Development of Psoriasis Following Anti-TNF Therapy. Ann Rheum Dis. 2006 Dec;65(12):1541-4.

Gladman DD, Mease PJ, Ritchlin CT, Choy EH, Sharp JT, Ory PA, Perdok RJ, Sasso EH. Adalimumab for long-term treatment of psoriatic arthritis: forty-eight week data from the adalimumab effectiveness in psoriatic arthritis trial. Arthritis Rheum. 2007 Feb;56(2):476-88.

Pariser DM, Bagel J, Gelfand JM, Korman NJ, Ritchlin CT, Storber E, VanVoorhees AS, Young M, Rittenberg S, Lebwohl M, Gitorn EJ; Nationsl Psoriases Fouondation. National Psoriasis Foundation Clinical Consensus on Disease Severity. Arch Dermatol. 2007 Feb;143(2):239-42.

Keeling SV, Landerwe R, van der Heijde D, Bathon J, Buers M, Garner OP, Geusen SP, El-Gabalawy H, Inman Rd, Kraus VB, Kvien Tk, Mease Pj, Ostergaare M, Ritchlin CT, Swersen SW, Maksymowych WP. Testing of the preliminary OMERACT validation criteria for a biomarker to be regarded as reflecting structural damage endpoints in rheumatoid arthritis clinical trials: the example of C-reactive protein. J Rheumatol. 2007 Mar;34(3):623-33

Ritchlin C, Haas-Smith S, Lee HA, Golub LM, Moak SA, Greenwald RA. Non-antimicrobial tetracycline derivatives upregulate IL-10 production in human synoviocytes and mononuclear cells. (manuscript submitted).

Anandarajah, A, Schwarz EM, Totterman S, Haas-Smith, SA, Ritchlin CT. The Effect of Etanercept Therapy on Clinical Outcome, Osteoclast Precursor Frequency and Bone Marrow Edema in Patients with Psoriatic Arthritis. (manuscript submitted).

Ritchlin, CT.Psoriatic arthritis: From Skin to bone. Nature Clinical Practice Rheumatology. (invited review) (in press).

Proul ST, Kwok E, You Z, Beck CA, Sjealy DJ, Ritchlin CT, Boyce BF, Xing L, Schwarz EM,

MRI and Quantification of Draining Lymph Node Function in Inflammatory Arthritis.
Ann N Y Acad Sci. 2007 Jul 23; Epub ahead of print

Schwarz EM, Ritchlin CT. Clinical development of anti-RANKL therapy.Arthritis Res Ther. 2007;9 Suppl 1:S7.

Gladmann DD, Mease Pj, Strand V, Healy P, Helliwell PS, Fitzgerald O, Gottlieb AB, Krueger GG, Nash P, Ritchlin CT, Taylor W, Adebajo A, Braun J, Eaul A, Carneiro S, Choy E, Pijkmans B, Wspinoza L, vander Heijde D, Shuni E, Lubrano E, McGonagle D, Qureshi A, Soliano ER, Zochling J. Consensus on a core set of domains for psoriatic arthritis.

JParisen DM, Bagel J, Gelfand JM, Korman NJ, Ritchlin CT, Strober BE, VAn Voorhees, AS, Young M, Rittenberg S, Lebioohl MG, Horn EJ. National Psioriasis Foundation. National Psoriasis Foundation clinical consensus on disease severity.
Arch Dermatol. 2007 Feb;143(2):239-42.

Stephen Rosenfeld, MD

Shearer, W.T., Buckley, R.H., Engler, R.J., Finn, A.F.J., Fleisher, T.A., Freeman, T.M., Herrod, H.G., Levinson, A.l., Lopez, M., Rich, R.R., Rosenfeld, S.I., and Rosenwasser, L.J. Practice Parameters For The Diagnosis And Management Of Immunodeficiency. The Clinical and Laboratory Immunology Committee of the American Academy of Allergy, Asthma, and Immunology (CLIC-AAAAI). Annals of Allergy, Asthma, & Immunology76(3):282-294, 1996.

Smith, P.H., Schwartz, R.H., Rosenfeld, S.I., and Johnstone, D.W. Bilateral, Recurrent Spontaneous Pneumothorax In A Male Adolescent With Chronic Asthma - A Case For Protease-Antiprotease Imbalance. Pediatric Asthma Allergy & Immunology 10(4): 191 -195, 1996.

Sloand, J.A., Mehta, R.L., Schmer, G., and Rosenfeld, S.l. Influence Of C1q On The Interaction Of Model Immune Complexes With Human Platelets. Clinical Immunology & Immunopathology 76(2): 127-134, 1995.

Wang, X., Fleischer, D.T., Whitehead, W.T., Haviland, D.L., Rosenfeld, S.l., Leddy, J.P., Snyderman, R., and Wetsel, R.A. Inherited Human Complement C5 Deficiency. Nonsense Mutations In Exons 1 (Gln1 To Stop) And 36 (Arg1458 To Stop) And Compound Heterozygosity In Three African-American Families. Journal of Immunology 154(10):5464-5471, 1995.

Ignacio Sanz, MD

Meek K, Sanz I, Rathbun G, Nisonoff A, Capra JD. Identity of the V kappa
10-Ars-A gene segments of the A/J and BALB/c strains. Proceedings of the National Academy of Sciences of the United States of America 1987;84(17):6244-8.

Sanz I, Capra JD. V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions. Proceedings of the National Academy of Sciences of the United States of America 1987;84(4):1085-9.

Makar R, Sanz I, Thomas JW, Capra JD. A structural basis for human cross-reacting idiotypes. Annales de l'Institut Pasteur-Immunology 1988;139(6):651-7.

Rathbun G, Sanz I, Meek K, Tucker P, Capra JD. The molecular genetics of the arsonate idiotypic system of A/J mice. Advances in Immunology 1988;42:95-164.

Sanz I, Hwang LY, Hasemann C, Thomas J, Wasserman R, Tucker P, Capra JD. Polymorphisms of immunologically relevant loci in human disease. Autoimmunity and human heavy chain variable regions. Annals of the New York Academy of Sciences 1988;546:133-42.

Sanz I, Capra JD. The genetic origin of human autoantibodies. Journal of Immunology 1988;140(10):3283-5.

McCauliffe DP, Lux FA, Lieu TS, Sanz I, Hanke J, Newkirk MM, Siciliano MJ, Sontheimer RD, Capra JD. Ro/SS-A and the pathogenic significance of its antibodies. Journal of Autoimmunity 1989;2(4):375-81.

Sanz I, Dang H, Takei M, Talal N, Capra JD. VH sequence of a human anti-Sm autoantibody. Evidence that autoantibodies can be unmutated copies of germline genes. Journal of Immunology 1989;142(3):883-7.

Sanz I, Kelly P, Williams C, Scholl S, Tucker P, Capra JD. The smaller human VH gene families display remarkably little polymorphism. EMBO Journal 1989;8(12):3741-8.

Sanz I, Casali P, Thomas JW, Notkins AL, Capra JD. Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families. Journal of Immunology 1989;142(11):4054-61.

McCauliffe DP, Lux FA, Lieu TS, Sanz I, Hanke J, Newkirk MM, Bachinski LL, Itoh Y, Siciliano MJ, Reichlin M and others. Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen. Journal of Clinical Investigation 1990;85(5):1379-91.

Meek K, Takei M, Dang H, Sanz I, Dauphinee MJ, Capra JD, Talal N. Anti-peptide antibodies detect a lupus-related interspecies idiotype that maps to H chain CDR2. Journal of Immunology 1990;144(4):1375-81.

Victor-Kobrin C, Barak ZT, Bonilla FA, Kobrin B, Sanz I, French D, Rothe J, Bona C. A molecular and structural analysis of the VH and VK regions of monoclonal antibodies bearing the A48 regulatory idiotype. Journal of Immunology 1990;144(2):614-24.

Bangs LA, Sanz IE, Teale JM. Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires. Journal of Immunology 1991;146(6):1996-2004.

Kim SO, Sanz I, Williams C, Capra JD, Gottlieb PD. Polymorphism in V kappa 10 genes encoding L chains of antibodies bearing the Ars-A and A48 cross-reactive idiotypes. Immunogenetics 1991;34(4):231-41.

Sanz I. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. Journal of Immunology 1991;147(5):1720-9.

Williams C, Weigel L, Sanz I, Capra J. Small human VH gene families show remarkably little polymorphism. Progress in Vaccinology. 1991 (7): 22-30.

Braun J, Berberian L, King L, Sanz I, Govan HL. Restricted use of fetal VH3 immunoglobulin genes by unselected B cells in the adult. Predominance of 56p1-like VH genes in common variable immunodeficiency. Journal of Clinical Investigation 1992;89(5):1395-402.

Weng NP, Yu-Lee LY, Sanz I, Patten BM, Marcus DM. Structure and specificities of anti-ganglioside autoantibodies associated with motor neuropathies. Journal of Immunology 1992;149(7):2518-29.

Dang H, Lazaridis K, Talal N, Fischbach M, Sanz I. Cloning of a human IgM autoantibody bearing a cross-reactive idiotype in a lambda expression vector: a new approach to studying autoantibodies. Clinical Immunology & Immunopathology 1993;67(3 Pt 1):249-56.

Sanz I, Wang SS, Meneses G, Fischbach M. Molecular characterization of human Ig heavy chain DIR genes. Journal of Immunology 1994;152(8):3958-69.

Peters M, Egan M, Mccabe R, Sanz I. B-cell repertoire in intestinal B-cells. Journal of Cellular Biochemistry 1995;Suppl. 19A:249.

Zeidel M, Rey E, Tami J, Fischbach M, Sanz I. Genetic and functional characterization of human autoantibodies using combinatorial phage display libraries. Annals of the New York Academy of Sciences 1995;764:559-64.

Raaphorst FM, Tami J, Sanz I. Cloning of size-selected human immunoglobulin heavy-chain rearrangements from third complementarity-determining region fingerprint profiles. Biotechniques 1996;20(1):78-82, 84, 86-7.

Raaphorst FM, Raman CS, Tami J, Fischbach M, Sanz I. Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences. International Immunology 1997;9(10):1503-15.

Deng S, Hanson E, Sanz I. Penetration of viable cells by anti-La and Anti-Smith autoantibodies. Scandinavian Journal of Immunology 1999;50:105.

O'Brien DP, Briles DE, Szalai AJ, Tu AH, Sanz I, Nahm MH. Tumor necrosis factor alpha receptor I is important for survival from Streptococcus pneumoniae infections. Infection & Immunity 1999;67(2):595-601.

Pugh A, Ryan D, Insel R, Sanz I. Regulation of expression of the autoreactive VH4-34 gene product. A model system for the study of human B cell tolerance. Arthritis & Rheumatism 1999;42:175.

Bili A, Moss AJ, Francis CW, Zareba W, Watelet LFM, Sanz I. Anticardiolipin antibodies and recurrent coronary events - A prospective study of 1150 patients. Circulation 2000;102(11):1258-1263.

del Rincon I, Zeidel M, Rey E, Harley JB, James JA, Fischbach M, Sanz I. Delineation of the human systemic lupus erythematosus anti-smith antibody response using phage-display combinatorial libraries. J Immunol 2000;165(12):7011-6.

Deng SX, Hanson E, Sanz I. In vivo cell penetration and intracellular transport of anti-Sm and anti-La autoantibodies. Int Immunol 2000;12(4):415-423.

Goater J, Muller R, Kollias G, Firestein GS, Sanz I, O'Keefe RJ, Schwarz EM. Empirical advantages of adeno associated viral vectors for in vivo gene therapy for arthritis. Journal of Rheumatology 2000;27(4):983-989.

Li P, Sanz I, O'Keefe RJ, Schwarz EM. NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes. Journal of Immunology 2000;164(11):5990-5997.

Pryhuber GS, O'Brien DP, Baggs R, Phipps R, Huyck H, Sanz I, Nahm MH.
Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury. American Journal of Physiology - Lung Cellular & Molecular Physiology 2000;278(5):L1082-90.

Rey E, Zeidel M, Rhine C, Tami J, Krolick K, Fischbach M, Sanz I. Characterization of Human Anti-acetylcholine Receptor Monoclonal Autoantibodies from the Peripheral Blood of a Myasthenia Gravis Patient Using Combinatorial Libraries. Clin Immunol 2000;96(3):269-279.=

Pugh-Bernard AE, Silverman GJ, Cappione AJ, Villano ME, Ryan DH, Insel RA, Sanz I. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J Clin Invest 2001;108(7):1061-1070

Pugh A, Ryan D, Insel R, Sanz I. Check-points for B-cell tolerance in SLE. Lupus 2001; 10:43.

Anolik JH, Cambpell D, Felgar RE, Young F, Sanz I, Rosenblatt J, Looney RJ. The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus. Arthritis & Rheumatism 48:455, 2003.

Anolik JH, Sanz I, Looney, RJ. B-cell depletion therapy in SLE. Current Rheumatology Reports. 5 (5) :350, 2003.

Anolik JH, Looney RJ, Sanz I, Young F. Down-regulation of surface CD20 B-cells upon CD40 activation. Eur J Immunol 33: 2398, 2003.

Zhang, M.Y., Shu, Y., Phogat, S., Xiao, X., Cham, F., Bouma, P., Choudhary, A., Feng, Y.R., Sanz, I., Rybak, S., et al. Broadly cross-reactive HIV neutralizing human monoclonal antibody Fab selected by sequential antigen panning of a phage display library. J Immunol Methods 283:17-25, 2003.

Cappione, A.J., Pugh-Bernard, A.E., Anolik, J.H., and Sanz, I. Lupus IgG VH4.34 Antibodies Bind to a 220-kDa Glycoform of CD45/B220 on the Surface of Human B Lymphocytes. J Immunol 172:4298-4307, 2004.

Looney, R.J., Anolik, J., and Sanz, I. B lymphocytes in Systemic Lupus Erythematosus: lessons from therapy targeting B cells. Lupus 13:1-10, 2004.

Looney, R.J., Anolik, J., and Sanz, I. B cells as therapeutic targets for rheumatic diseases. Curr Opin Rheumatol 16:180-185, 2004.

Pugh-Bernard, A.E., Cappione, A., Anolik, J., and Sanz, I. From Cold-Agglutinin Disease to Systemic Lupus Erythematosus: Lessons in Human B-Cell Tolerance and Its Breakdown. Transfusion Medicine and Hemotherapy 31:84-90, 2004.

Looney, R.J., Anolik, J.H., Campbell, D., Felgar, R.E., Young, F., Sloan, J., Rosenblatt, J., Sanz, I. Treatment of SLE with an Anti-CD20 Monoclonal Antibody. Arthritis & Rheumatism. In Press.

Anolik, J., and Sanz, I. B lymphocytes in human and murine SLE. Curr Opin Rheumatol. In Press.

Cappione A, Anolik J, Pugh-Bernard A, Sanz I. Defective censoring of autoreactive B-cells in the germinal centers in human SLE. Nature Immunology. Submitted.

Anolik, J., Barnard, J., Cappione, A., Pugh-Bernard, A., Felgar, R., Looney, R.J., Sanz, I. Rituximab improves peripheral B-cell abnormalities in human SLE. Arthritis & Rheumatism. Submitted.

David Siegel, M.D.

Siegel DM. Adolescents and Chronic Illness. JAMA 1987;257: 3396-3399.

Siegel DM. The high cost of medical technology-getting at the heart of the matter. Medical Care 1987; 25:979-987.

Siegel DM, Baum J. HLA-B27 Associated dactylitis in children. J. Rheum 1988;15: 976-977.

Siegel DM, Parker RM, Gillman MW, Biro FM. Demographic features and attitudes of program directors of combined internal medicine and pediatric residencies. AJDC 1988;142:1104-1108.

Chavin SI, Siegel DM, Rocco TA, Olson JP. Acute myocardial infarction during treatment with an activated prothrombin complex concentrate in a patient with factor VIII deficiency and a factor VIII inhibitor Amer J Med 1988;85:245-249.

Siegel DM. Bulimia, tricyclic antidepressants, and mania. Clin Ped 1989; 28: 123-126.

Biro FM, Gillman MW, Parker RM Khoury PR, Siegel DM. Surveying graduates of combined internal medicine-peidatrics residency programs. Acad Med 1990; 65:266-271.

Siegel DM, McDaniel SH. The frog prince: tale and toxicology. Amer J of Orthpsych 1991; 61: 558-562.

VanOstrand EW, Siegel DM, Baum J. Juvenil SLE: A 23-year survey showing regional similarities and differences from prior series. J Univ Roch Med Center 1992; 4:2-6.

Biro FM, Siegel DM, Parker RM, Gillman MW. A comparison of self-perceived clinical competencies in primary care residency graduates. Pediatric Res 1993; 34:555-559.

Deane PMG, Siegel DM, Baum J. The outcome of Children referred to a pediatric rheumatology clinic with a positive antinuclear antibody test but without an autoimmune disease. Pediatrics 1995; 95:892-895.

Aten MJ, Siegel DM, Roghmann KJ. Use of health services by urban youth: a school based survey to assess differences by grade level, gender and risk behavior. J Adol Health 1996; 19:258-266.

Cox EM, Siegel DM. Mondor's disease: an unusual consideration in a young woman with a breast mass. J Adol Heath 1997; 21:183-185.

Siegel DM. Drug treatment of juvenile arthritis: accepted therapeutic options. Drugs of Today. 1998; 34:327-340.

Siegel DM, Janeway D, Baum J. Fibromyalgia syndrome in Children and adolescents: clinical features at presentation and status at follow-up. Pediatrics 1998;101:377-382.

Siegel DM, Aten MJ, Roghmann KJ. Self-reported honesty among middle and high school students responding to a sexual behavior questionnaire. J Adol Health 1998; 23:20-28.

Siegel DM, Aten MJ, Roghmann KJ, Enaharo M. Early effects of a school-based human immunodeficeincy virus infection and sexual risk prevention intervention. Arch Pediatr Adolesc Med 1998;152:961-970.

Siegel DM, Klein DI, RoghmannKJ. Sexual behavior, contraception and HIV risk among college students. J of Adol Health 1999; 25: 336-343.

Siegel DM, Aten MJ, Enharo M. Long term effects of a middle and high school-based, HIV sexual risk prevention intervention. Arch Pediatr Adolesc Med 2001;155:1117-1126.

vonHahnL, Harper G, McDaniel SH, Siegel DM, Feldman MD, Libow JA. A case of factitious disorder by proxy: the role of the health-care system, diagnostic dilemmas and family dynamics. Harvard Rev Psychiatry 2001;9:124-35.

Aten MJ, Siegel DM, Enaharo M. Keeping middle school students abstinent: outcomes of a primary prevention intervention. J of Adol Health 2002;31:70-78.

Rosen DS, Blum RW, Britto M, Sawyer SM, Siegel DM. Trtansition to adult health care for adolescent and yound adults with chronic conditions: position paper fof the society for adolescent medicine. J Adol Health 2003;33:309-311.

Bleesing J, Prada A, Siegel DM, Villaueva J, Olson JA, Ilowite NT, Brunner H, Griffin T, Graham T, Sherry DD, P{asso MH, Ramana AV, Piipovish A, Grom AA. The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor Alpha-2 receptor alpha-chain in macrophage activation syndrome and untreated new onset systemic juvenile idopathic arthritis. Arth Rheum 2007;965-971.

Garfunkel LC, Pisani AR, LeRoux P, Kudes D, Siegel DM. Integrated pediatric and mental health training: a 10 year perspective. Manuscript in preparation.

Pisani AR, LeRoux P, Siegel DM.. Improving behavioral health training and service: A model for educating pediatricians and psychologists together. Manuscript in preparation.

Darren Tabechian , MD

Tabechian D, Pattanaik D, Suresh U, Cohn SA and Nadasdy T . Lupus-like nephritis in a HIV positive patient: report of a case and review of the literature. Clinical Nephrology, September ,2003

Pattanaik D, Tabechian D and Varnis C. Cardiac tamponade: an uncommon presentation of hypertensive scleroderma renal crisis- report of a case and review of the literature. Journal of Clinical Rheumatology, 2004.

Chungwen Wei, PhD

Gray, G.M., Wei, C. and Macara, I.G. (1989) Specific desensitization of the epidermal growth factor receptor by pp60v-src. J. Cell. Biochem. 40:271-278.

Stathopoulos, V.M., Coco-Moroney, A, Wei, C., Goth, M., Zaricznyj, C. and Macara, I.G. (1990) Identification of two cytosolic diacylglycerol kinase isoforms in rat brain, and in NIH3T3 and ras-transformed fibroblasts. Biochem. J. 272:569-575.

Wei, C., Lutz, R., Sinensky, M. and Macara, I.G. (1992) p23rab2, a ras-like GTPase with a –GGGCC C-terminus, is isoprenylated but not detectably carboxymethylated in NIH3T3 cells. Oncogene 7:467-473.

Wei, C., Storozynsky, E., McAdam, A.J., Yeh, K.Y., Tilton, B.R., Willis, R.A., Barth, R.K., Looney, R.J., Lord, E.M. and Frelinger, J.G. (1996) Expression of human prostate-specific antigen (PSA) in a mouse tumor cell line reduces tumorigenicity and elicits PSA-specific cytotoxic T lymphocytes. Cancer Immunol. Immunother. 42:362-368.

Wei, C., Willis, R.A., Tilton, B.R., Looney, R.J., Lord, E.M., Barth, R.K. and Frelinger, J.G. (1997) Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy. Proc.Natl. Acad. Sci. USA 94:6369-6374.

Willis, R.A., Wei, C., Turner, M.J., Callahan, B.P., Pugh, A.E., Barth, R.K., Lord, E.M. and Frelinger, J.G. (1998) A transgenic strategy for analyzing the regulatory regions of the human prostate-specific antigen gene: potential applications for the treatment of prostate cancer. Int. J. Mol. Med. 1:379-386.

Wei, C., Callahan, B.P., Turner, M.J., Willis, R.A., Lord, E.M., Barth, R.K. and Frelinger, J.G. (1998) Regulation of human prostate-specific antigen gene expression in transgenic mice: Evidence for an enhancer between the PSA and human glandular kallikrein-1 genes. Int. J. Mol. Med. 2:487-496.

Wei, C., Saller, D.N. and Sutherland, J.W.H. (2001) Detection and quantitation by homogeneous PCR of cell-free fetal DNA in maternal plasma. Clin. Chem. 47:336-338.

Brown, D.M., Fisher, T., Wei, C., Frelinger, J.G. and Lord, E.M. (2001) Tumors can act as adjuvants for humoral immunity. Immunology 102:486-497.

Huggins, J., Pellegrin, T., Felgar, R.E., Wei, C., Brown, M., Zheng, B., Milner, E.C.B., Bernstein, S.H., Sanz, I. and Zand M.S. (2007) CpG DNA activation and plasma-cell differentiation of CD27- naïve human B cells. Blood 109:1611-1619.

Wei, C., Anolik, J., Cappione, A., Zheng, B., Pugh-Bernard, A., Brooks, J., Lee, E-H., Milner, E.C.B., and Sanz, I. (2007) A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J. Immunol. 178:6624-6633.

Sanz, I., Wei, C., Lee, F.E., Anolik, J. (2008) Phenotypic and functional heterogeneity of human memory B cells. Semin. Immunol. 20:67-82.