Sanz Lab
The Team: Ignacio Sanz, M.D., Professor of Medicine, Microbiology & Immunology
James Kobie, Ph.D., Research Assistant Professsor of Medicine
Chungwen, Wei, Ph.D. Research Assistant Professor of Medicine
Katie Gall, Health Project Coordinator
Scott Jenks, Ph.D., Post-doctoral Fellow
Sunil Keshetti, M.D. Health Project Coordinator
Nataly Manjarrez-Orduno, Ph.D, Post-doctoral Fellow
Elides Marin, Technician
Elise Palmer, Research Assistant
Tam Quach, Graduate Student
Christopher Richardson, Graduate Student
Mustimbo Roberts, Graduate Student
James Roger, Graduate Student
Bo Zheng, Technician
Ignacio Sanz, M.D.
Dr. Sanz's current research interests and efforts are focused examining human B cell development, function and tolerance. He is also exploring the use of B cell depletion in the treatment of autoimmune diseases and is attempting to identify new biomarkers for Sjogrens syndrome. He is also co-director of the Rochester Center for the Biodefense of Immunocomprimised Populations and director of the Rochester NIH Autoimmune Center of Excellence. The Rochester ACE has made further investigations into the pathogenesis of systemic lupus erythematosi possible.
Dr. Sanz has active studies in rheumatoid arthritis and Sjogren's syndrome. For more information on the studies in rheumatoid arthritis, contact Keith Alexander at 585-275-4983. For more information on the studies in Sjogren's syndrome and psoriasis, contact Sunil Keshetti at 585-275-1035.
Dr Sanz has served as a mentor for many students in the past and continues to mentor future scientists in his lab.
Funding
Dr. Sanz is funded through the NIH, Amgen, Immunex, Centocor, Bristol-Meyuers Squibb, National Psoriasis Fund, American College of Rheumatology, Corrona, and Abbot..
Publications
Dr. Sanz's most recent publications include:
Pugh-Bernard, A.E., Cappione, A., Anolik, J., and Sanz, I. From Cold-Agglutinin Disease to Systemic Lupus Erythematosus: Lessons in Human B-Cell Tolerance and Its Breakdown. Transfusion Medicine and Hemotherapy 31:84-90, 2004.
Looney, R.J., Anolik, J.H., Campbell, D., Felgar, R.E., Young, F., Sloan, J., Rosenblatt, J., Sanz, I. Treatment of SLE with an Anti-CD20 Monoclonal Antibody. Arthritis & Rheumatism. In Press.
Anolik, J., and Sanz, I. B lymphocytes in human and murine SLE. Curr Opin Rheumatol. In Press.
Cappione A, Anolik J, Pugh-Bernard A, Sanz I. Defective censoring of autoreactive B-cells in the germinal centers in human SLE. Nature Immunology. Submitted. In Press.
For a complete list of Dr. Sanz's publications, use the following link: publications.
James Kobie, Ph.D.
Dr. Kobie is co-director of the of the Rochester Center for the Biodefense of Immunocompromised Populations.
Dr. Kobie’s research interest include studying CD4 T cells and their contribution to the generation of effective anti-tumor immune responses and their translational applications for the development of cancer vaccines. He is also examining the effect of pregnancy and pregnancy-related factors on the differentiation of CD4 T cells. In collaboration with Dr. Iñaki Sanz he is studying the development of B cells that give rise to HIV specific antibodies capable of neutralizing a broad range of HIV isolates to elucidate strategies to generate effective HIV vaccines.
Funding
Dr. Kobie receives his funding from
the NIH including the NIAID and the NCI
.
Publications
Dr. Kobie's most recent publications include:
Hamalainen-Laanaya, H.K., Kobie, J.J., Chang, C., and Zeng, W.P. Temporal and Spatial Changes of Histone 3 K4 Dimethylation at the IFN-{gamma} Gene during Th1 and Th2 Cell Differentiation. J Immunol. 179, 6410-6415 (2007).
Kobie, J. J., Shah, P.R., Yang, L., Rebhahn, J.A., Fowell, D.J., and Mosmann, T.R.. T regulatory and primed uncommitted CD4 T cells express CD73 which suppresses effector CD4 T cells by converting 5’AMP to adenosine. J Immunol. 177, 6780-6 (2006)
Zaiss, D.M., Yang, L., Shah, P., Kobie, J.J., Urban, J.F., and Mosmann, T.R. Amphiregulin - a Th2 cytokine important for nematode resistance. Science. 314, 1746 (2006)
Hahn T, Alveraz I., Kobie JJ , Ramanathapuiam L, Dial S, Fulton A, Besselsen D, Walker E, Akporraye ET. Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer. Int J Cancer. 118, 2220-31 (2006)
Yang, L., Kobie, J.J., and Mosmann, T.R.. CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from Type 1 or Type 2 effector cells. J Immunol. 161, 6458-6464 (2005)
For a complete list of Dr. Kobie's publications, use the following link: publications.
Chungwen Wei, Ph.D.
Dr. Wei's current research interests include the study of human B cell development and anergy through immunophenotyping utilizing polychromatic flow cytometry, gene expression profiling and functional analysis.
Publications
Dr. Wei's most recent publications include:
Wei, C., Saller, D.N. and Sutherland, J.W.H. (2001) Detection and quantitation by homogeneous PCR of cell-free fetal DNA in maternal plasma. Clin. Chem. 47:336-338.
Brown, D.M., Fisher, T., Wei, C., Frelinger, J.G. and Lord, E.M. (2001) Tumors can act as adjuvants for humoral immunity. Immunology 102:486-497.
Huggins, J., Pellegrin, T., Felgar, R.E., Wei, C., Brown, M., Zheng, B., Milner, E.C.B., Bernstein, S.H., Sanz, I. and Zand M.S. (2007) CpG DNA activation and plasma-cell differentiation of CD27- naïve human B cells. Blood 109:1611-1619.
Wei, C., Anolik, J., Cappione, A., Zheng, B., Pugh-Bernard, A., Brooks, J., Lee, E-H., Milner, E.C.B., and Sanz, I. (2007) A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J. Immunol. 178:6624-6633.
Sanz, I., Wei, C., Lee, F.E., Anolik, J. (2008) Phenotypic and functional heterogeneity of human memory B cells. Semin. Immunol. 20:67-82.
For a complete list of Dr. Wei's publications, use the following link: publications.
|