New York Influenza Center of Excellence

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PROTOCOL SUMMARY

Title :	Surveillance of influenza infection and immunity in families.
Population :	Up to 150 families with at least one child 4 years of age or younger in which at least 3 family members agree to participate in ongoing surveillance
Number of Sites :	The study will be conducted at the New York Influenza Center of Excellence, within the Rochester area. Multiple pediatric and family medicine practices may participate in this study.
Study Duration :	The study will continue for as long as 6 years
Subject Duration :	Subjects may continue to participate in surveillance until the study ends. The duration of participation will be between 1 and 5 years, depending on when the subject enrolls.

Study Objectives

The goal of this protocol is to perform a detailed evaluation of the cellular response to primary and secondary infection and immunization with influenza virus and influenza vaccines, including:

Identify, in humans, specific T cell responses to influenza epitopes shared among serologically distinct viruses following primary and secondary infections.
Identify H1, H3, and H5 hemagglutinin-specific human B cell responses by FACS and ELISPOT
Compare and contrast potential heterosubtypic immune responses induced by influenza infection or vaccination in humans.
Use novel cellular markers (such as VLA-1/CCR7/CD62L) to identify T cells in the peripheral blood with the potential to become extralymphoid memory T cells.