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Dr.
Benjamin Miller is an expert in molecular design, synthetic organic
chemistry, combinatorial chemistry, and structural analysis of biological
molecules. His primary interest is in the application of these tools
to the fundamental understanding of the ways in which biological
molecules interact, and in the application of this understanding
to the development of new diagnostic tools. Dr. Miller strongly believes
that the interdisciplinary environment of the Department of Dermatology
and the Center for Future Health is an ideal setting for advancing
fundamental science and human health.
Visit the New Miller Group website.
Education
|
Institution
|
Location
|
Degree
|
Year
|
| Miami University |
Oxford, Ohio |
B.S., B.A., |
1988 |
| Stanford University |
Stanford, California |
Ph.D., Organic Chemistry |
1994 |
Academic Appointments and Professional Experience
| 1988-1994 |
Research Assistant, Department
of Chemistry, Stanford University: Professor Paul A. Wender,
advisor. Synthesis of calphostin C and related perylenequinone
natural products; molecular modeling of the interactions of
dynemicin A with DNA; identification, synthesis, overexpression,
analysis, and tertiary structure determination of phorbol ester-binding
polypeptides related to protein kinase C. |
| 1994-1996 |
NIH Postdoctoral Fellow,
Department of Chemistry, Harvard University: Professor Stuart
L. Schreiber, advisor. Design, synthesis, and evaluation of
structure-based, nonpeptide combinatorial libraries for binding
to Src homology 3 (SH3) domains. |
| 1996-2002 |
Assistant Professor of Chemistry
University of Rochester, Rochester, New York |
| 2002 |
Associate Professor of Dermatology
University of Rochester, Rochester, New York |
Honors, Awards and Societies
- 2001-2006 Camille Dreyfus Teacher-Scholar Award
- 1994-1996 NIH Postdoctoral Fellow, Harvard University
- 1991-1993 W. R. Grace Graduate Fellow, Stanford University
Journal Articles (selected)
- Klekota, B.; Hammond, M. H.; Miller, B. L. "Generation of
Novel DNA-Binding Compounds by Selection and Amplification from
Self-Assembled Combinatorial Libraries" Tetrahedron Lett.,
1997, 38, 8639-8643.
- Hubbard, R. D.; Miller, B. L. "Lewis Acid Catalyzed
Diels-Alder Reactions of Highly Hindered Dienophiles" J.
Org. Chem. 1998, 63, 4143.
- Pickert, J. D.; Miller,
B. L. "Cloning as a Tool for
Chemists" in Comprehensive Natural Products Chemistry, Kool,
E. T., Ed., Elsevier Press, 1998 v. 7, pp. 643-674.
- Klekota, B.;
Miller, B. L. "Dynamic Diversity and Small-Molecule
Evolution: a New Paradigm for Ligand Identification" Trends
in Biotechnology, 1999, 17, 205-209.
- Klekota, B.; Miller, B. L. "Selection of DNA-Binding
Compounds via Multistage Molecular Evolution" Tetrahedron (Combinatorial Chemistry Symposium in Print), 1999, 55, 11687.
- Hari,
A.; Miller, B. L. "A New Method for the Mild and
Selective Reduction of Aryl Nitro Groups on Solid Support" Tetrahedron
Lett., 1999, 40, 245-248.
- Hari, A.; Miller, B. L. "Transfer Catalysis Between
Two Solids: Application to the Reduction of Nitroarenes" Angew.
Chem. Int. Ed. Engl. 1999, 38, 2777-2779.
- Hari, A.; Miller, B.
L. "Exploiting Differences in Solution
vs. Solid-Supported Reactivity for the Synthesis of Sulfonic
Acid Derivatives" Org. Lett., 1999, 1, 2109-2111.
- Karan,
C.; Miller, B. L. "Dynamic Diversity in Drug
Discovery: Putting Small-Molecule Evolution to Work" Drug
Discovery Today, 2000, 5, 67-75.
- Hari, A.; Miller, B. L. "Segregation of Separate Steps
in Chromium-Catalyzed Reactions for Convenience and Mechanistic
Analysis" Org. Lett., 2000, 2, 691-693.
- Chan, S.; Fauchet, P. M.; Li, Y.; Rothberg, L. J.; Miller,
B. L. "Porous Silicon Microcavities for Biosensing Applications" Physica
Status Solidi A, 2000, 182, 541-546.
- Hari, A.; Miller, B. L. "Rapid and Efficient Synthesis
of 2-Amino-4H-benzothiazines" Org. Lett., 2000, 2, 3667-3670.
- Chan,
S.; Horner, S. R.; Miller, B. L.; Fauchet, P. M. "Nanoscale
Silicon Microcavity Optical Sensors for Biological Applications" Mat.
Res. Soc. Symp. Proc., 2000, 638, F10.4.
- Hubbard, R. D.; Horner,
S. R.; Miller, B. L. "Highly
Substituted ter-Cyclopentanes as Receptors for Lipid A and
Simple Carbohydrates in Aqueous Solution" J. Am. Chem.
Soc.,
2001, 123, 5810-5811.
- Hari, A.; Rodrigues, W. C.; Karan, C.; Miller,
B. L. "Extending
the Scope of Chromium-Manganese Redox-Coupled Reactions: A
One-Pot Synthesis of Benzoxazoles" J. Org. Chem., 2001,
66, 991-996.
- Karan, C.; Miller, B. L. "RNA-Selective Coordination
Complexes Identified via Dynamic Combinatorial Chemistry" J.
Am. Chem. Soc., 2001, 123, 7455-7456.
- Chan, S.; Horner, S. R.;
Miller, B. L.; Fauchet, P. M. "Identification
of Gram Negative Bacteria using Nanoscale Silicon Microcavities" J.
Am. Chem. Soc., 2001, 123, 11797-11798.
- Chan, S.; Li, Y.; Rothberg,
L. J.; Miller, B. L.; Fauchet, P. M. "Nanoscale Silicon Microcavities for Biosensing" Mat.
Sci. & Eng. 2001, C15, 277-282 (invited).
- Hubbard, R. D.;
Miller, B. L. “Regioselective and
Diastereoselective Synthesis of Highly Substituted Cyclopentanes” Tetrahedron,
2003, 59, 8143.
- McNaughton, B. R.; Miller, B. L. “A Mild and Efficient
One-Step Synthesis of Quinolines” Org. Lett., 2003, 5,
4257-4259.
- Du, K; Disney, M. D.; Miller, B. L.; Krauss, T. D. “Hybridization-based
unquenching of DNA hairpins on Au surfaces: prototypical “molecular
beacon” biosensors” J. Am. Chem. Soc., 2003, 125,
4012.
- Tajc, S. G.; Tolbert, B. S.; Basavappa, R.; Miller, B. L. “Direct
determination of pKa by isothermal titration microcalorimetry” J.
Am. Chem. Soc., 2004, 126, 10508-10509.
- DeLouise, L. A.; Miller,
B. L. “Trends in porous silicon
biomedical devices – tuning microstructure and performance
trade-offs in optical biosensors” Proc. SPIE, 2004, 5357,
111-125.
- Lu, J.; Strohsahl. C. M.; Miller, B. L.; Rothberg, L.
J. “Reflective
Interferometric Detection of Label-Free Oligonucleotides” Anal.
Chem., 2004, 76, 4416.
- DeLouise, L.; Miller, B. L. “Optimization of mesoporous
silicon microcavities for proteomics sensing” Mat.
Res. Soc. Symp. Proc., 2004, 782, A5.3.1-A5.3.7.
- DeLouise, L.; Miller,
B. L. “Quantitative assessment
of enzyme immobilization capacity in porous silicon” Anal.
Chem., 2004, in press.
- DeLouise, L. A.; Miller, B. L. “Enzyme Immobilization
in Porous Silicon: Quantitative Analysis of the Kinetic Parameters
for Glutathione-S-Transferases” Anal. Chem., 2005, in press
Book Chapters:
- Wender, P. A.; Miller, B. L. "Toward the Ideal Synthesis:
Connectivity Analysis and Multibond-Forming Processes" in
Organic Synthesis: Theory and Applications, Hudlicky, Ed., 1993,
p. 27.
- Pickert, J. D.; Miller, B. L. "Cloning as a Tool for Chemists" in
Comprehensive Natural Products Chemistry, Kool, E. T., Ed., Elsevier
Press, 1998 v. 7, pp. 643-674.
- Miller, B. L.; Fauchet, P. M.; Horner, S. R.; Chan, S. “Porous
Silicon Microcavities for Biosensing Applications” in Encyclopedia
of Nanotechnology, Schwarz, J. A.; Contescu, C. I.; Putyera, K.,
Eds. Marcel Dekker, Inc.; New York, 2004, 343-350.
- Bucholtz, K. M.; Miller, B. L. “Development of General
Synthetic Strategies Towards Oligocycloalkanes” Strategies
and Tactics in Organic Synthesis, Harmata, M., Ed., 2004, 5, 183-220s.
- Ross, N. T.; McNaughton, B. R.; Miller, B. L. “Combinatorial
Chemistry in the Drug Discovery Process”, Wiley Handbook
of Drug Discovery (invited), 2005, in press.
Patents:
- Miller, B. L.; Klekota, B. "Combinatorial Libraries"
- Miller,
B. L.; Hubbard, R. D. "Oligocycloalkanoid Peptidomimetic
Compounds and Method of Making the Same"
- Miller, B. L.; Klekota,
B. "Biphasic Combinatorial Chemistry"
- Miller, B. L.;
Horner, S. R.; Fauchet, P.; Chan, S. "Porous
Silicon Biosensors"
- Miller, B. L.; Krauss, T. D. "Nanocrystal-Based Colorimetric
Sensors"
- Miller, B. L.; Krauss, T. D.; Ballinger, C. M.; Landry, D.;
LoCasio, M. "Sensor Arrays"
- Rothberg, L. J.; Miller, B.
L. "Ellipsometric Sensor Arrays"
- Horner, S. R.; Miller,
B. L. "Mimics of Enterohemmorhagic
and Enteropathogenic E. coli Translocated Intimin Receptor (TIR)"
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