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Research Opportunities by Human Disease: Cancer | Cardiovascular
Diseases | Endocrine Disorders |
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A wide variety of diseases stem from genetic malformations. Several organs are a common target for specific gene mutations that lead to tissue degeneration growth impairment or abnormal transformation. These mutations can be of different natures ranging from a single point mutation to a gene deletion or a chromosomal translocation. Researchers in the Pathways of Human Disease cluster at the University of Rochester are investigating the molecular and cellular mechanisms involved in pathogenesis due to genetic diseases. Multiple efforts are directed towards finding cures for developmental diseases, cancer or endocrine-related severe conditions to cite only a few. These efforts aim to find better diagnostic means to determine the occurrence and severity of these conditions, as well as developing the future generation of therapeutic interventions such as gene therapy. A number of in vitro and in vivo models are also developed to study these diseases before the translation of this research into clinical application through collaborations with geneticists, clinicians and epidemiologists. Our cluster provides the means to assess and study genetic abnormalities, but also a multitude of interesting research projects in several laboratories using state-of-the-art technology to investigate genetic diseases. Faculty investigating genetic diseases: Bradford
Berk
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DNA microarrays are used to accelerate the analysis of gene expression. |
