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Research Opportunities by Investigative Approach:Molecular Biology and Genetics | Protein
Structure and Function |
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From the first transgenic mouse models reported in the early 1980s to the use of gene targeting and cloning technologies, we are witnessing rapid growth in the use of animal models in disease-based research. While studies of genetically modified animal models may not always correlate exactly to human biology and disease pathogenesis, their value to scientific discovery are immeasurable and provide invaluable insights into many human diseases. A number of faculty members within the Pathways of Human Disease cluster focus their studies on transgenic animal models. These animals carry alterations in their genetic information that modify the normal pattern of gene expression within some or all of the cells of their body. Research projects that explore the function and regulation of the transferred genetic material provide exciting opportunities to explore animal development and disease processes such as cancer, diabetes, osteoporosis, cardiovascular disease. Faculty using animal models in the investigation of human diseases: Bradford
Berk
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Mouse cells expressing HUMAN smooth muscle calponin.
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