Cellular Signaling and Regulation

• G protein Coupled Receptors
• Calcium Signaling
• Protein Kinases
• Second Messenger Pathways

Signal transduction is the molecular basis for cellular communication, ie., how hormones, growth factors, or pharmacological compounds regulate cell physiology, mitogenesis, and differentiation through binding to receptors. Defects in this cellular communication are responsible for a number of cancers and cardiovascular diseases. G protein coupled receptors are major targets for current therapeutics and therapeutic development. Understanding mechanisms of action of these receptor regulated systems will lead to novel strategies for therapeutic development.

Abe, Jun-ichi
Mechanism and significance of kinase and transcriptional factors in diabetes-related cardiovascular disease.

Berk, Bradford C.
Molecular biology and genetics of cardiovascular disease.

Bidlack, Jean M.
Pharmacology of brain and lymphocytic opioid receptors.

Blaxall, Burns C.
Cardiac gene expression and G-protein coupled receptor signaling.

Chang, Chawnshang
Androgen receptor and AR coregulators in androgen-related diseases, such as prostate/breast/liver cancer.

Dickerson, Ian
Molecular mechanisms of neuropeptide signal transduction.

Freeman, Robert S.
Molecular mechanisms of neuronal death.

Hinkle, Patricia M.
Molecular mechanisms of cell regulation.

Hocking, Denise C.
Regulation of cell behavior by the extracellular matrix.

Ivanov, Andrei I.
Basic mechanism regulating the formation and functions of epithelial apical junctions as well as on mechanisms mediating disruption of epithelial cell-cell adhesions in inflammation and cancer.

Jin, Zheng-Gen
Molecular regulation of vascular endothelial function and vascular diseases.

Kammermeier, Paul J.
G protein coupled receptor signaling and modulation of ion channels in neurons.

Krieger, Nancy S.
Mechanisms of regulation of bone calcium metabolism, with an emphasis on signal transduction pathways involved in hormonal and acid-mediated effects on bone-cell function.

Lopes, Coeli M.B.
Molecular mechanisms of cardiac potassium channel regulation in health and disease.

Melvin, James E.
Exocrine gland physiology - water movement and ion transport.

Nehrke, Keith
Integrative physiology in the nematode C. elegans.

Pentland, Alice P.
The role of phospholipases and cyclooxgenases in epidermal function

Pryhuber, Gloria
Tumor necrosis factor alpha (TNF- a) signal transduction and subsequent gene regulation in pulmonary epithelium.

Rahman, Arshad
Signaling mechanisms of endothelial ICAM-1 expression and neutrophil-mediated lung vascular injury.

Rahman, Irfan
Oxidative stress, glutathione regulation, NF-kB, redox signaling and gene expression.

Sarelius, Ingrid H.
Vascular cell communication and signaling.

Schaefer, Katherine L.
Regulation of the cytoskeleton in cancer.

Smrcka, Alan V.
Molecular mechanisms of signal transduction.

Sottile, Jane
Molecular mechanisms by which the extracellular matrix controls cell behavior.

Sun, Jun
Molecular mechanism of signal transduction in inflammation and cancer.

Sun, Yin
TGF- b regulation of proliferation and differentiation.

Tall, Gregory G.
Mechanisms of signal transduction, heterotrimeric G protein signaling.

Waugh, Richard E.
Regulation and molecular basis of the mechanical stability of cells, cell membranes, and cell adhesion

Yan, Chen
Regulation and function of cyclic nucleotide phosphodiesterases in the cardiovascular system.

Young, Fay
Normal and abnormal B-lymphocyte development.

Yule, David I.
Mechanisms underlying Ca 2+ signaling events in exocrine cells.